Document Detail


DNA-fluorescence-cytometry and prognosis (grading) of meningiomas--a study of 104 surgically removed tumors.
MedLine Citation:
PMID:  3670625     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A total of 104 meningiomas of various histological types were examined microscopically and with flow fluorescence cytometry using the EBR staining technique and either an ICP 11 or an ICP 22 (PHYWE). Also tissue culture cells of 72 tumors were studied for their DNA content. There was a variable DNA distribution, which allowed a grading of malignancy according to a 3 or 4 grade scale. Useful information on the nature of a meningioma and its proliferative activity can be obtained during the surgical treatment. A majority of meningiomas show slowly proliferative DNA patterns typical for benign tumors. More than one third of the meningiomas show an intermediate configuration, probably associated with more or less semi-benign proliferative activity. 5.8% of our cases showed primary malignant tumors--except meningosarcomas.
Authors:
F W Spaar; A Ahyai; M Blech
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurosurgical review     Volume:  10     ISSN:  0344-5607     ISO Abbreviation:  Neurosurg Rev     Publication Date:  1987  
Date Detail:
Created Date:  1987-12-07     Completed Date:  1987-12-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7908181     Medline TA:  Neurosurg Rev     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  35-9     Citation Subset:  IM    
Affiliation:
Department of Neuropathology, University of Göttingen, West Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aneuploidy
Cell Division
DNA / metabolism*
Female
Flow Cytometry*
Humans
Meningeal Neoplasms / genetics,  metabolism*,  pathology,  surgery
Meningioma / genetics,  metabolism*,  pathology,  surgery
Middle Aged
Polyploidy
Prognosis
Chemical
Reg. No./Substance:
9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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