Document Detail

DNA fingerprinting of Mycobacterium tuberculosis isolates from epidemiologically linked case pairs.
MedLine Citation:
PMID:  12453346     Owner:  NLM     Status:  MEDLINE    
DNA fingerprinting was used to evaluate epidemiologically linked case pairs found during routine tuberculosis (TB) contact investigations in seven sentinel sites from 1996 to 2000. Transmission was confirmed when the DNA fingerprints of source and secondary cases matched. Of 538 case pairs identified, 156 (29%) did not have matching fingerprints. Case pairs from the same household were no more likely to have confirmed transmission than those linked elsewhere. Case pairs with unconfirmed transmission were more likely to include a smear-negative source case (odds ratio [OR] 2.0) or a foreign-born secondary case (OR 3.4) and less likely to include a secondary case <15 years old (OR 0.3). Our study suggests that contact investigations should focus not only on the household but also on all settings frequented by an index case. Foreign-born persons with TB may have been infected previously in high-prevalence countries; screening and preventive measures recommended by the Institute of Medicine could prevent TB reactivation in these cases.
Diane E Bennett; Ida M Onorato; Barbara A Ellis; Jack T Crawford; Barbara Schable; Robert Byers; J Steve Kammerer; Christopher R Braden
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Emerging infectious diseases     Volume:  8     ISSN:  1080-6040     ISO Abbreviation:  Emerging Infect. Dis.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-27     Completed Date:  2003-01-17     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  9508155     Medline TA:  Emerg Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1224-9     Citation Subset:  IM    
Centers for Disease control and Prevention, Atlanta, GA 30333, USA.
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MeSH Terms
Contact Tracing
DNA Fingerprinting*
DNA, Bacterial / analysis
Middle Aged
Mycobacterium tuberculosis / classification*,  genetics*
Sentinel Surveillance
Tuberculosis / epidemiology*,  microbiology*,  transmission
United States / epidemiology
Reg. No./Substance:
0/DNA, Bacterial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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