Document Detail

DNA dynamics in a microchannel.
MedLine Citation:
PMID:  12906459     Owner:  NLM     Status:  MEDLINE    
An extended Brownian dynamics simulation method is used to characterize the dynamics of long DNA molecules flowing in microchannels. The relaxation time increases due to confinement in agreement with scaling predictions. During flow the molecules migrate toward the channel center line, and thereby segregate according to molecular weight. Capturing these effects requires the detailed incorporation of solvent flow in the simulation method, demonstrating the importance of hydrodynamic effects in the dynamics of confined macromolecules.
Richard M Jendrejack; Eileen T Dimalanta; David C Schwartz; Michael D Graham; Juan J de Pablo
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2003-07-15
Journal Detail:
Title:  Physical review letters     Volume:  91     ISSN:  0031-9007     ISO Abbreviation:  Phys. Rev. Lett.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-08-08     Completed Date:  2003-09-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401141     Medline TA:  Phys Rev Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  038102     Citation Subset:  IM    
Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
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MeSH Terms
Computer Simulation
DNA / chemistry*
Models, Chemical
Stochastic Processes
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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