Document Detail


DNA dinucleotide evolution in humans: fitting theory to facts.
MedLine Citation:
PMID:  11606548     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examine length distributions of approximately 6000 human dinucleotide microsatellite loci, representing chromosomes 1-22, from the GDB database. Under the stepwise mutation model, results from theory and simulation are compared with the empirical data. In both constant and expanding population scenarios, a simple single-step model with parameters chosen to account for the observed variance of microsatellite lengths produces results inconsistent with the observed heterozygosity and the dispersion of length skewness. Complicating the model by allowing a variable mutation rate accounts for the homozygosity, and introducing a small probability of a large mutation step accounts for the dispersion in skewnesses. We discuss these results in light of the long-term evolution of microsatellites.
Authors:
A Renwick; L Davison; H Spratt; J P King; M Kimmel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Genetics     Volume:  159     ISSN:  0016-6731     ISO Abbreviation:  Genetics     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-18     Completed Date:  2002-01-15     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  737-47     Citation Subset:  IM    
Affiliation:
Department of Statistics, Rice University, Houston, Texas 77251, USA.
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MeSH Terms
Descriptor/Qualifier:
Chromosomes, Human
Databases, Nucleic Acid
Dinucleotide Repeats / genetics*
Evolution, Molecular*
Genetics, Population
Humans
Models, Genetic
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