| A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M. | |
| | |
MedLine Citation:
|
PMID: 9770487 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cell cycle progression is monitored by highly coordinated checkpoint machinery, which is activated to induce cell cycle arrest until defects like DNA damage are corrected. We have isolated an anti-proliferative cell cycle regulator named G2A (for G2 accumulation), which is predominantly expressed in immature T and B lymphocyte progenitors and is a member of the seven membrane-spanning G protein-coupled receptor family. G2A overexpression attenuates the transformation potential of BCR-ABL and other oncogenes, and leads to accumulation of cells at G2/M independently of p53 and c-Abl. G2A can be induced in lymphocytes and to a lesser extent in nonlymphocyte cell lines or tissues by multiple stimuli including different classes of DNA-damaging agents and serves as a response to damage and cellular stimulation which functions to slow cell cycle progression. |
| | |
Authors:
|
Z Weng; A C Fluckiger; S Nisitani; M I Wahl; L Q Le; C A Hunter; A A Fernal; M M Le Beau; O N Witte |
Related Documents
:
|
19465107 - Systems biology of the cell cycle of saccharomyces cerevisiae: from network mining to s... 19597327 - The cyclin-dependent kinase inhibitors, cki-1 and cki-2, act in overlapping but distinc... 19887337 - Identifying cell cycle regulators and combinatorial interactions among transcription fa... 22504647 - Mesenchymal cells regulate retinoic acid receptor-dependent cortical thymic epithelial ... 17919337 - The radiosensitizing effect of doranidazole on human colorectal cancer cells exposed to... 15012297 - Structure and biogenesis of the cell walls of grasses. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 95 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1998 Oct |
Date Detail:
|
Created Date: 1998-11-12 Completed Date: 1998-11-12 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 12334-9 Citation Subset: IM |
Affiliation:
|
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
|
GENBANK/AF083442 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
3T3 Cells Amino Acid Sequence Animals Base Sequence Cell Cycle Proteins / chemistry, genetics, metabolism* Cloning, Molecular DNA Damage* DNA Primers DNA Replication G2 Phase* GTP-Binding Proteins / metabolism* Mice Mitosis* Molecular Sequence Data Oxidative Stress* Rats Receptors, G-Protein-Coupled* Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
|
CA40046/CA/NCI NIH HHS; CA76204/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Cell Cycle Proteins; 0/DNA Primers; 0/G2A receptor; 0/Receptors, G-Protein-Coupled; EC 3.6.1.-/GTP-Binding Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Subnuclear localization of the active variant surface glycoprotein gene expression site in Trypanoso...
Next Document: GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP.