Document Detail

DNA content and proliferative index in cutaneous squamous cell carcinoma and keratoacanthoma.
MedLine Citation:
PMID:  2301286     Owner:  NLM     Status:  MEDLINE    
The histologic separation of keratoacanthomas (KA) and well-differentiated squamous cell carcinoma (WDSCC) using established criteria may present a diagnostic dilemma in the individual case. The authors questioned whether the DNA index (DI) and/or the proliferative index (PI), as shown by flow cytometry (FCM) might assist in this differential diagnosis. Thirty-six well-differentiated squamous cell lesions of skin were independently classified as either WDSCC or KA by a panel of three pathologists. Six poorly differentiated squamous cell carcinomas (PDSCC) also were included in this study. Sections from paraffin blocks were prepared by standard techniques and analyzed by FCM. Mean DI values were: KA 0.96%, WDSCC 0.99%, and PDSCC 0.88%. The differences in the mean DIs were not statistically significant. Mean PI values were as follows: KA 16.7%, WDSCC 14.8%, and PDSCC 20.2%. Differences were not statistically significant. The authors conclude that the FCM measurements of DI and PI do not help in separating KA and WDSCC of skin.
M B Randall; K R Geisinger; T E Kute; D H Buss; R W Prichard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  93     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-03-07     Completed Date:  1990-03-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  259-62     Citation Subset:  AIM; IM    
Department of Pathology, Wake Forest University, Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103.
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MeSH Terms
Aged, 80 and over
Carcinoma, Squamous Cell / metabolism,  pathology*
Cell Division
DNA, Neoplasm / analysis*
Diagnosis, Differential
Flow Cytometry
Keratoacanthoma / metabolism,  pathology*
Middle Aged
Retrospective Studies
Skin Neoplasms / metabolism,  pathology*
Reg. No./Substance:
0/DNA, Neoplasm

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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