Document Detail


DNA content and enzymic activities in the auditory regions of seizure-susceptible and non-susceptible strains of mice.
MedLine Citation:
PMID:  6817154     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The developmental profiles of four glycosidase enzymes (beta-D-glucosidase, beta-D-glucuronidase, beta-D-N-acetylglucosaminidase and beta-D-galactosidase) in the cochleas, cochlear nuclei and inferior colliculi of four strains of mice were investigated. The strains used were an audiogenically seizure-susceptible strain (DBA/2) and three non-susceptible strains (BALB/c, C3H/He and Swiss/A2G). The enzymic activities fell to varying degrees from 7 to 28 days of age. Two significant observations were made--beta-D-glucuronidase was low in the regions of the C3H/He strain, and beta-D-galactosidase was particularly low in the regions of the DBA/2 strain. The very low activity of beta-D-galactosidase in the DBA/2 mice is discussed in relation to the ganglioside patterns known to be present in these seizure-susceptible mice. Studies on the DNA contents of these auditory regions in the four strains showed no correlation with seizure sensitivity.
Authors:
D F Wheeler; N E Contreras; H S Bachelard
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurochemical research     Volume:  7     ISSN:  0364-3190     ISO Abbreviation:  Neurochem. Res.     Publication Date:  1982 Sep 
Date Detail:
Created Date:  1983-02-25     Completed Date:  1983-02-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1075-88     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylglucosaminidase / metabolism*
Acoustic Stimulation
Aging
Animals
Cochlea / enzymology,  growth & development*
DNA / analysis*
Galactosidases / metabolism*
Glucosidases / metabolism*
Hexosaminidases / metabolism*
Inferior Colliculi / enzymology,  growth & development*
Mice
Mice, Inbred Strains
Mice, Neurologic Mutants
Seizures / physiopathology*
Species Specificity
beta-Galactosidase / metabolism*
beta-Glucosidase / metabolism*
Chemical
Reg. No./Substance:
9007-49-2/DNA; EC 3.2.1.-/Galactosidases; EC 3.2.1.-/Glucosidases; EC 3.2.1.-/Hexosaminidases; EC 3.2.1.21/beta-Glucosidase; EC 3.2.1.23/beta-Galactosidase; EC 3.2.1.52/Acetylglucosaminidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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