Document Detail

DNA-based delivery vehicles: pH-controlled disassembly and cargo release.
MedLine Citation:
PMID:  23143043     Owner:  NLM     Status:  MEDLINE    
Non-Watson-Crick base pairing provides an in situ approach for actuation of DNA nanostructures through responses to solution conditions. Here we demonstrate this concept by using physiologically-relevant changes in pH to regulate DNA pyramid assembly/disassembly and to control the release of protein cargo.
Jung-Won Keum; Harry Bermudez
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-11-12
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  48     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-20     Completed Date:  2013-04-22     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  12118-20     Citation Subset:  IM    
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MeSH Terms
Circular Dichroism
DNA / chemistry*
Fluorescence Resonance Energy Transfer
Green Fluorescent Proteins / chemistry
Hydrogen-Ion Concentration
Nanostructures / chemistry
Nucleic Acid Conformation
Solutions / chemistry
Grant Support
1R21CA158977-01/CA/NCI NIH HHS; R21 CA158977/CA/NCI NIH HHS
Reg. No./Substance:
0/Solutions; 0/enhanced green fluorescent protein; 147336-22-9/Green Fluorescent Proteins; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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