Document Detail


DNA analysis for phospholipase A2 coding sequences of Mycoplasma hominis isolated from women with a normal pregnancy and women with a pregnancy complicated by preterm labour.
MedLine Citation:
PMID:  9789649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A possible cause of preterm labour is an increased synthesis of prostaglandins by a phospholipase A2 (PLA2) activity. PLA2 activity has been detected in Mycoplasma hominis. The aim of this study was to test whether chromosomal DNA of M. hominis contains sequences coding for PLA2. M. hominis was cultured in specimens from 5 women with normal pregnancy and 4 in preterm labour. Using sequence alignment, primer pairs for the active part of PLA2 of different species were designed for PCR analysis. No sequences coding for PLA2 could be amplified. Whatever its role in preterm labour, M. hominis is not involved in causing an increase of prostaglandin synthesis.
Authors:
H Stepan; R Faber; C Retzlaff; T Walther
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  261     ISSN:  0932-0067     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  1998  
Date Detail:
Created Date:  1999-01-26     Completed Date:  1999-01-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  189-91     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Leipzig.
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MeSH Terms
Descriptor/Qualifier:
DNA, Bacterial / genetics*
Female
Humans
Infant, Newborn
Mycoplasma hominis / genetics*
Obstetric Labor, Premature / microbiology*
Phospholipases A / genetics*
Phospholipases A2
Pregnancy
Prostaglandins / biosynthesis
Risk Factors
Sequence Analysis, DNA
Chemical
Reg. No./Substance:
0/DNA, Bacterial; 0/Prostaglandins; EC 3.1.1.-/Phospholipases A; EC 3.1.1.4/Phospholipases A2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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