Document Detail


DNA analysis cervical and vaginal cancer cells during radiotherapy by rapid high-resolution cytometry.
MedLine Citation:
PMID:  3385280     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The DNA content of the nuclei of cancer cells of 12 cases of cervical cancer and 2 cases of vaginal cancer, treated with radiotherapy, were studied in 50 specimens. Specimens were taken from each case before radiotherapy and at the totals of 1,000 rad, 2,000 rad, 3,000 rad and 4,500 rad (or 5,000 rad). All specimens were stained by the Papanicolaou method and were analyzed by rapid high-resolution cytometry. Total optical density, mean nuclear area and the 5N-exceeding rate (5NER) increased gradually following irradiation. Cancer cells disappeared in good response cases before 3,000 rad. Eight smears with a 5NER under 100 at the dose of 3,000 rad or more seemed to be poor response cases. Low 5NER and low mean nuclear areas were observed in both patients who died with persistent disease after radiotherapy, as well as in one case treated with chemotherapy for persistent disease after radiotherapy.
Authors:
T Izutsu; T Kagabu; I Nishiya; G L Wied
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nihon Sanka Fujinka Gakkai zasshi     Volume:  40     ISSN:  0300-9165     ISO Abbreviation:  Nippon Sanka Fujinka Gakkai Zasshi     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-08-11     Completed Date:  1988-08-11     Revised Date:  2011-07-29    
Medline Journal Info:
Nlm Unique ID:  7505749     Medline TA:  Nihon Sanka Fujinka Gakkai Zasshi     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  621-6     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Iwate Medical University.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell / analysis*,  radiotherapy
DNA, Neoplasm / analysis*
Dose-Response Relationship, Radiation
Female
Flow Cytometry
Humans
Middle Aged
Predictive Value of Tests
Radiotherapy Dosage
Uterine Cervical Neoplasms / analysis*,  radiotherapy
Vaginal Neoplasms / analysis*,  radiotherapy
Chemical
Reg. No./Substance:
0/DNA, Neoplasm

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