Document Detail

DNA-adduct formation in lungs, nasal mucosa, and livers of rats exposed to urban roadside air in Kawasaki City, Japan.
MedLine Citation:
PMID:  12865046     Owner:  NLM     Status:  MEDLINE    
The potency of ambient air for DNA-adduct formation was estimated using Wistar rats. The animals were maintained in a small-animal facility located beside a main highway intersection in Kawasaki City, Japan, for up to 60 weeks and were exposed to roadside air contaminated mainly with automobile emission (exposure group, EG) or to clean air (control group, CG). Compared to CG, the relative adduct levels (RAL) were increased significantly in EG lungs (17.1-fold (P<0.05)), nasal mucosa, and livers after exposure for 4 weeks. However, there were no significant differences in RAL between EG and CG after exposure for 12 weeks, but they were elevated again in EG after exposure for 48 or 60 weeks. These results suggest that roadside air in this region can cause the generation of DNA adducts. This activity of ambient roadside air can be estimated using experimental animals, indicating that biological monitoring of DNA-adduct formation may be a powerful tool to assess the effect of ambient air on human health.
Hiromi Sato; Kazuo T Suzuki; Hideko Sone; Yuko Yamano; Jun Kagawa; Yasunobu Aoki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental research     Volume:  93     ISSN:  0013-9351     ISO Abbreviation:  Environ. Res.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-07-16     Completed Date:  2003-09-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  36-44     Citation Subset:  IM    
Research Centre for Environmental Risk, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan.
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MeSH Terms
Administration, Inhalation
Air Pollutants / analysis,  metabolism,  toxicity*
Blotting, Northern
Carbon / analysis
Cytochrome P-450 CYP1A1 / genetics,  metabolism
Cytochrome P-450 CYP1A2 / genetics,  metabolism
DNA Adducts / biosynthesis*
Environmental Exposure / adverse effects*
Liver / metabolism*
Lung / metabolism*
Nasal Mucosa / metabolism*
RNA, Messenger / genetics,  metabolism
Rats, Wistar
Reverse Transcriptase Polymerase Chain Reaction
Urban Population
Vehicle Emissions / toxicity*
Reg. No./Substance:
0/Air Pollutants; 0/DNA Adducts; 0/RNA, Messenger; 0/Vehicle Emissions; 7440-44-0/Carbon; EC P-450 CYP1A1; EC P-450 CYP1A2

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