| DIC secondary to acute pancreatitis. | |
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MedLine Citation:
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PMID: 16048498 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Various hematological abnormalities including fall in serial values of hemoglobin or hematocrit, coagulation factor abnormalities, leukocytosis, acute hemolytic anemia, thrombocytopenia, and thrombotic thrombocytopenic purpura or hemolytic uremic syndrome have been reported in patients with acute pancreatitis. Similarly, abnormalities of blood coagulation factors consistent with disseminated intravascular coagulopathy (DIC) have also been noticed in patients with pancreatitis. We report a case of a 33-year-old female with acute pancreatitis who presented with one episode of epistaxis and abnormal prothrombin time and partial prothrombin time. Coagulation work-up revealed thrombin time 24.3 s fibrinogen 110 mg/dl, D-dimers >1 and < 2, and fibrin degradation products >22. Pancultures did not show any evidence of infection. The patient maintained a normal renal and mental status during her illness. Her D-dimers continued to decrease with resolution of acute pancreatitis as evidenced by decreased abdominal pain, relief of nausea, control of vomiting, and decrease in serum amylase and lipase levels. This case report suggests that coagulation abnormalities are encountered in patients with acute pancreatitis. It is hypothesized that such hemostatic abnormalities may be related to early intravascular consumption of coagulation factors secondary to circulating pancreatic enzymes, particularly trypsin, or secondary to vascular injury. Recognition of these hematological complications including DIC is paramount. Physicians caring for these patients should be aware of such a complication of acute pancreatitis. |
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Authors:
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M W Saif |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical and laboratory haematology Volume: 27 ISSN: 0141-9854 ISO Abbreviation: Clin Lab Haematol Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-07-28 Completed Date: 2005-11-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7907061 Medline TA: Clin Lab Haematol Country: England |
Other Details:
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Languages: eng Pagination: 278-82 Citation Subset: IM |
Affiliation:
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Division of Hematology/Oncology and Department of Clinical Pharmacology/Toxicology, University of Alabama at Birmingham (UAB), 263 Wallace Tumor Institute, 1824 6th Avenue South, Birmingham, AL 35294, USA. wasif.saif@ccc.uab.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Disseminated Intravascular Coagulation / diagnosis, etiology* Female Humans Pancreatitis / complications*, diagnosis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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