| DHEAS levels and mortality in disabled older women: the Women's Health and Aging Study I. | |
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MedLine Citation:
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PMID: 16960027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Dehydroepiandrosterone sulfate (DHEAS) is an endogenously produced sex steroid that has been hypothesized to have anti-aging effects. Low DHEAS levels are associated with mortality in older men, but the relationship between DHEAS levels and mortality in women is not clearly defined. METHODS: The relationship between serum DHEAS level and 5-year mortality was analyzed in a cohort of 539 disabled women aged 65-100 years enrolled in the Women's Health and Aging Study I (WHAS I). Using Cox proportional hazard models, we calculated multivariate-adjusted mortality risks by DHEAS quartiles and by DHEAS continuously, allowing for a nonlinear relationship. We also examined cause-specific mortality. RESULTS: We found a U-shaped relationship between DHEAS level and mortality. After adjusting for multiple covariates, women in the top and bottom DHEAS quartiles had a more than 2-fold higher 5-year mortality than did those in the middle quartiles (hazard ratio, 2.15; 95% confidence interval [CI], 1.17-3.98 for the top quartile and 2.05; 95% CI, 1.27-3.32 for the bottom quartile, each compared to the third quartile). Women with higher DHEAS levels tended to have greater cancer mortality, whereas those with lower DHEAS tended to have greater cardiovascular mortality. CONCLUSION: Disabled older women with either low or high levels of DHEAS are at greater risk for death than are those with intermediate levels. More research is needed to determine if targeted dehydroepiandrosterone supplementation would provide clinical benefit to disabled older women. |
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Authors:
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Anne R Cappola; Qian-Li Xue; Jeremy D Walston; Sean X Leng; Luigi Ferrucci; Jack Guralnik; Linda P Fried |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The journals of gerontology. Series A, Biological sciences and medical sciences Volume: 61 ISSN: 1079-5006 ISO Abbreviation: J. Gerontol. A Biol. Sci. Med. Sci. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-08 Completed Date: 2006-10-12 Revised Date: 2012-03-07 |
Medline Journal Info:
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Nlm Unique ID: 9502837 Medline TA: J Gerontol A Biol Sci Med Sci Country: United States |
Other Details:
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Languages: eng Pagination: 957-62 Citation Subset: AIM; IM |
Affiliation:
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Division of Endocrinology, Diabetes, and Metabolism, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6021, USA. acappola@cceb.med.upenn.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Cardiovascular Diseases / blood, mortality* Cohort Studies Dehydroepiandrosterone Sulfate / blood* Disabled Persons / statistics & numerical data* Female Humans Multivariate Analysis Neoplasms / blood, mortality* Proportional Hazards Models Questionnaires United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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K23 AG19161/AG/NIA NIH HHS; N01-AG-1-2112/AG/NIA NIH HHS; R01-AG11703/AG/NIA NIH HHS; R37-AG19905/AG/NIA NIH HHS; Z99 AG999999/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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651-48-9/Dehydroepiandrosterone Sulfate |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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