Document Detail


DHA supplementation: current implications in pregnancy and childhood.
MedLine Citation:
PMID:  23266567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dietary supplementation with ω-3 long chain fatty acids including docosahexaenoic acid (DHA) has increased in popularity in recent years and adequate DHA supplementation during pregnancy and early childhood is of clinical importance. Some evidence has been built for the neuro-cognitive benefits of supplementation with long chain polyunsaturated fatty acids (LCPUFA) such as DHA during pregnancy; however, recent data indicate that the anti-inflammatory properties may be of at least equal significance. Adequate DHA availability in the fetus/infant optimizes brain and retinal maturation in part by influencing neurotransmitter pathways. The anti-inflammatory properties of LCPUFA are largely mediated through modulation of signaling either directly through binding to receptors or through changes in lipid raft formation and receptor presentation. Our goal is to review the current findings on DHA supplementation, specifically in pregnancy and infant neurodevelopment, as a pharmacologic agent with both preventative and therapeutic value. Given the overall benefits of DHA, maternal and infant supplementation may improve neurological outcomes especially in vulernable populations. However, optimal composition of the supplement and dosing and treatment strategies still need to be determined to lend support for routine supplementation.
Authors:
Lynette K Rogers; Christina J Valentine; Sarah A Keim
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-12-21
Journal Detail:
Title:  Pharmacological research : the official journal of the Italian Pharmacological Society     Volume:  70     ISSN:  1096-1186     ISO Abbreviation:  Pharmacol. Res.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-18     Completed Date:  2013-09-10     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  8907422     Medline TA:  Pharmacol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  13-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Central Nervous System / drug effects*,  embryology,  growth & development
Child Development / drug effects*
Dietary Supplements
Docosahexaenoic Acids / administration & dosage,  adverse effects,  pharmacology*
Female
Fetal Development / drug effects*
Humans
Infant
Organ Size / drug effects
Placenta / drug effects
Pregnancy
Premature Birth / prevention & control*
Retina / drug effects*,  embryology,  growth & development
Grant Support
ID/Acronym/Agency:
R01 AT006880/AT/NCCAM NIH HHS
Chemical
Reg. No./Substance:
25167-62-8/Docosahexaenoic Acids
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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