| DEAE-Dextran in the treatment of primary hypercholesterolemia and/or hypercholesterolemia combined with hypertriglyceridemia. A multicentric randomized study on the efficacy of DEAE-Dextran compared with Cholestyramine. | |
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MedLine Citation:
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PMID: 14618939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was carried out to verify the therapeutic homogeneity between DEAE-Dextran and Cholestyramine. Blood levels of total cholesterol, HDL, LDL and triglycerides were evaluated in 202 patients affected by dyslipidemia and treated with DEAD-D at 2.5 g/day or with Cholestyramine at 12 g/day for 30 days. At the end of treatment both drugs caused significant reduction of total cholesterol, LDL and triglycerides blood levels; DEAD-D was generally more effective than Cholestyramine, in particular on triglycerides values (30.6% and 13.7% of reduction respectively), and produced also a significant increase in HDL cholesterol, differently from Cholestyramine that was ineffective on this parameter. |
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Authors:
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F Fedele |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: La Clinica terapeutica Volume: 154 ISSN: 0009-9074 ISO Abbreviation: Clin Ter Publication Date: 2003 Jul-Aug |
Date Detail:
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Created Date: 2003-11-17 Completed Date: 2004-01-29 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0372604 Medline TA: Clin Ter Country: Italy |
Other Details:
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Languages: eng Pagination: 231-6 Citation Subset: IM |
Affiliation:
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Dipartimento di Scienze Cardiovascolari e Respiratorie, Università degli studi La Sapienza, Via Del Policlinico, 155, 00161 Roma. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticholesteremic Agents
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therapeutic use* Cholestyramine Resin / therapeutic use* DEAE-Dextran / therapeutic use* Female Humans Hypercholesterolemia / blood, complications, drug therapy* Hypertriglyceridemia / blood, complications, drug therapy* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 11041-12-6/Cholestyramine Resin; 9015-73-0/DEAE-Dextran |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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