| DDDR pacing driven by contractility versus DDI pacing in vasovagal syncope: a multicenter, randomized study. | |
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MedLine Citation:
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PMID: 12687864 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent clinical trials have shown that selected patients with recurrent vasovagal syncope (VVS) may benefit from permanent cardiac pacing. In a previous study using head-up tilt testing (HUT) the authors demonstrated that the increase in sympathetic activity preceding syncope could be sensed by a microaccelerometer located in the tip of a ventricular pacing lead and used to drive a rate adaptive pacer. They compared in a single blind randomized crossover study, DDDR pacing driven by this system, with conventional DDI pacing in patients with recurrent VVS. Twenty-three patients (age 61.8 +/- 15.2 years, 19 men) with recurrent VVS were enrolled at seven European centers and underwent implantation of a "MiniLivingD/Best" pacing system. Inclusion criteria were (1) > 6 cumulative syncopal episodes or > or = 1 syncope within 6 months of a positive HUT, and (2) a positive HUT with bradycardia. Using a crossover study design, the pacemakers were randomly programmed for two successive periods of 6 months to DDDR or DDI mode. The numbers of episodes of syncope and presyncope, and quality-of-life (QOL), were assessed at the end of each period. During the 6 months before implant, the mean number of syncopal episodes per patient was 3.2 +/- 9. During pacing in the DDDR mode, 0.09 +/- 0.29 syncope/presyncope per patient was observed, while during the DDI period 0.48 +/- 0.73 episodes per patient were reported (P < 0.05). QOL scores were 77.40 +/- 11.32 in the DDDR mode versus 74.45 +/- 14.59 in the DDI mode (NS). In patients with recurrent VVS, symptomatic recurrences were less frequent during contractility-driven DDDR pacing, than during DDI pacing. QOL was similar in the two pacing modes. |
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Authors:
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Jean-Claude Deharo; Alberto Borri Brunetto; Fulvio Bellocci; Lorella Barbonaglia; Eraldo Occhetta; Lorella Fasciolo; Maurizio Bocchiardo; Giorgio Rognoni |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Pacing and clinical electrophysiology : PACE Volume: 26 ISSN: 0147-8389 ISO Abbreviation: Pacing Clin Electrophysiol Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2003-04-11 Completed Date: 2003-07-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7803944 Medline TA: Pacing Clin Electrophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 447-50 Citation Subset: IM |
Affiliation:
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Cardiology Dept., Sainte-Marguerite University Hospital of Marseilles, 270 Bd Sainte-Marguerite, 13008 Marseille, France. jean-claude.deharo@ap-hm.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Cardiac Pacing, Artificial / methods* Cross-Over Studies Female Humans Male Middle Aged Myocardial Contraction Pacemaker, Artificial* Quality of Life Recurrence Single-Blind Method Syncope, Vasovagal / physiopathology, therapy* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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