Document Detail

DDAVP in acquired von Willebrand syndrome associated with multiple myeloma.
MedLine Citation:
PMID:  3088986     Owner:  NLM     Status:  MEDLINE    
The response to a single intravenous infusion of 1-deamino-8-D-arginine vasopressin (DDAVP, desmopressin) was studied in two patients with acquired von Willebrand syndrome associated with IgG-kappa myeloma. Following infusion of DDAVP (0.3-0.4 micrograms/kg), prolonged bleeding time was normalized; plasma ristocetin cofactor activity, von Willebrand factor antigen, and factor VIII activity were remarkably increased; and high-molecular-weight forms of von Willebrand factor were demonstrated by crossed immunoelectrophoresis in both patients. Excellent hemostasis was achieved following administration of DDAVP in one patient when it was used for the treatment of gum bleeding and for the prophylaxis of bleeding during and after dental extractions. These observations suggest that DDAVP is an effective alternative to blood products for at least some patients with acquired von Willebrand syndrome in addition to patients with inherited von Willebrand disease, hemophilia A, and uremia.
H Takahashi; R Nagayama; Y Tanabe; K Satoh; M Hanano; M Mito; A Shibata
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hematology     Volume:  22     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-08-11     Completed Date:  1986-08-11     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  421-9     Citation Subset:  IM    
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MeSH Terms
Blood Coagulation Tests
Deamino Arginine Vasopressin / administration & dosage,  therapeutic use*
Hemostasis, Surgical
Immunoglobulin G / analysis
Immunoglobulin kappa-Chains
Infusions, Parenteral
Middle Aged
Multiple Myeloma / blood,  complications*
von Willebrand Diseases / blood,  drug therapy*,  etiology
Reg. No./Substance:
0/Immunoglobulin G; 0/Immunoglobulin kappa-Chains; 16679-58-6/Deamino Arginine Vasopressin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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