| DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27. | |
| | |
MedLine Citation:
|
PMID: 17259988 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
During adaptive immune responses, dendritic cells activate T cells and endow them with specific homing properties. Mechanisms that 'imprint' specific tropisms, however, are not well defined. We show here that 1,25(OH)(2)D(3), the active form of vitamin D3, signaled T cells to express CC chemokine receptor 10, which enabled them to migrate to the skin-specific chemokine CCL27 secreted by keratinocytes of the epidermis. In contrast, 1,25(OH)(2)D(3) suppressed the gut-homing receptors alpha4beta7 and CCR9. Vitamin D3, the inactive prohormone naturally generated in the skin by exposure to the sun, was processed by dendritic cells and T cells to the active metabolite, providing a mechanism for the local regulation of T cell 'epidermotropism'. Our findings support a model in which dendritic cells process and 'interpret' locally produced metabolites to 'program' T cell homing and microenvironmental positioning. |
| | |
Authors:
|
Hekla Sigmundsdottir; Junliang Pan; Gudrun F Debes; Carsten Alt; Aida Habtezion; Dulce Soler; Eugene C Butcher |
Related Documents
:
|
10984428 - Exosome: from internal vesicle of the multivesicular body to intercellular signaling de... 2950648 - Differential distribution of atpase- and t6-positive cells (langerhans cells) in the li... 6712088 - Epidermal langerhans cells in cholesteatoma. 7689348 - The phenotype of murine langerhans cells from skin to lymph node. 10490838 - Poly(adp-ribose) polymerase upregulates e2f-1 promoter activity and dna pol alpha expre... 19468308 - Dazl functions in maintenance of pluripotency and genetic and epigenetic programs of di... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2007-01-28 |
Journal Detail:
|
Title: Nature immunology Volume: 8 ISSN: 1529-2908 ISO Abbreviation: Nat. Immunol. Publication Date: 2007 Mar |
Date Detail:
|
Created Date: 2007-02-16 Completed Date: 2007-05-01 Revised Date: 2011-05-05 |
Medline Journal Info:
|
Nlm Unique ID: 100941354 Medline TA: Nat Immunol Country: United States |
Other Details:
|
Languages: eng Pagination: 285-93 Citation Subset: IM |
Affiliation:
|
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
|
GEO/GSE6743 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antigen Presentation / immunology Base Sequence Cell Movement / immunology Cells, Cultured Chemokine CCL27 Chemokines, CC / immunology, metabolism* Cholecalciferol / metabolism* Coculture Techniques Dendritic Cells / immunology, metabolism* Flow Cytometry Humans Interleukin-12 / immunology, metabolism Keratinocytes / immunology, metabolism* Lymphocyte Activation / immunology Molecular Sequence Data Receptors, CCR10 Receptors, Calcitriol / immunology, metabolism Receptors, Chemokine / biosynthesis*, genetics Reverse Transcriptase Polymerase Chain Reaction Sheep Sunlight T-Lymphocytes / immunology, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
|
5 T32 AI07290-21/AI/NIAID NIH HHS; R01 AI072618-05/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/CCL27 protein, human; 0/CCR10 protein, human; 0/Chemokine CCL27; 0/Chemokines, CC; 0/Receptors, CCR10; 0/Receptors, Calcitriol; 0/Receptors, Chemokine; 187348-17-0/Interleukin-12; 67-97-0/Cholecalciferol |
| Comments/Corrections | |
Comment In:
|
Nat Immunol. 2007 Mar;8(3):229-30
[PMID:
17304229
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Epithelial cells trigger frontline immunoglobulin class switching through a pathway regulated by the...
Next Document: A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility comple...