Document Detail

DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle progression and cell growth.
MedLine Citation:
PMID:  18823379     Owner:  NLM     Status:  MEDLINE    
DCUN1D3 (DCN1, defective in cullin neddylation 1, domain containing 3) was found during the process of high throughput screening of novel human genes associated with serum response element (SRE) pathway activation. The DCUN1D3 gene is highly conserved among vertebrates. Human DCUN1D3 complementary DNA (cDNA) encodes 304 amino acids with an apparent molecular mass of 34 kDa. However, there has been no report about the function of DCUN1D3. This study detected that DCUN1D3 was broadly expressed in several tumor tissues and cultured cell lines; however, UVC irradiation of different doses significantly increased DCUN1D3 expression level in these cancer cell lines. Over-expression of the DCUN1D3 inhibits cell growth in HeLa. When the DCUN1D3 gene was silenced by siRNA in UVC-treated HeLa, the cell cycle in S phase was remarkably blocked; furthermore, the UVC-induced cell death was inhibited. In addition, DCUN1D3 localized mainly in the cytoplasm and perinuclear, but after UVC treatment, the DCUN1D3 gradually entered the nucleus. All the results above indicate that DCUN1D3 is a novel UVC-response gene involved in cell cycle regulation and cell survival.
Teng Ma; Taiping Shi; Jing Huang; Lina Wu; Fanlei Hu; PengFei He; WeiWei Deng; Peng Gao; Yingmei Zhang; Quansheng Song; Dalong Ma; Xiaoyan Qiu
Related Documents :
3450099 - Pleiotropic effect of anticapsin on hela s3 cells.
12798929 - Induction of permeability changes and death of vertebrate cells is modulated by the vir...
10542279 - Analysis of the molecular mechanism for the antagonistic action of a novel 1alpha,25-di...
12584329 - Nef-mediated disruption of hla-a2 transport to the cell surface in t cells.
6798119 - The requirement for esterase activation in t cell replacing factor (trf)-induced igg pr...
20964799 - Combined action of the type iv secretion effector proteins bepc and bepf promotes invas...
12530099 - Psc 833 modulation of multidrug resistance to paclitaxel in cultured human ovarian carc...
2578889 - Requirement for metalloendoprotease in exocytosis: evidence in mast cells and adrenal c...
11784049 - Evidence that sry is expressed in pre-sertoli cells and sertoli and granulosa cells hav...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-22
Journal Detail:
Title:  Cancer science     Volume:  99     ISSN:  1349-7006     ISO Abbreviation:  Cancer Sci.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-28     Completed Date:  2009-01-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101168776     Medline TA:  Cancer Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  2128-35     Citation Subset:  IM    
Laboratory of Medical Immunology, School of Basic Medical Science, Peking University Health Science Center, Beijing, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amino Acid Sequence
Base Sequence
Cell Cycle / genetics*,  physiology
Cell Cycle Proteins / genetics*,  metabolism
Cell Proliferation / radiation effects
Cell Survival / radiation effects
Cloning, Molecular
DNA, Complementary / genetics,  metabolism
Hela Cells
Microscopy, Fluorescence
Molecular Sequence Data
Oncogene Proteins / genetics,  metabolism
RNA, Small Interfering / metabolism
Ultraviolet Rays*
Reg. No./Substance:
0/Cell Cycle Proteins; 0/DCUN1D3 protein, human; 0/DNA, Complementary; 0/Oncogene Proteins; 0/RNA, Small Interfering

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Autophagy and autophagic cell death are next targets for elimination of the resistance to tyrosine k...
Next Document:  Hepatoma-derived growth factor involved in the carcinogenesis of gastric epithelial cells through...