Document Detail

DBC1 is over-expressed and associated with poor prognosis in colorectal cancer.
MedLine Citation:
PMID:  23299276     Owner:  NLM     Status:  Publisher    
BACKGROUND: Deleted in breast cancer 1 (DBC1) was initially cloned from a region homozygously deleted in breast cancers, but its role in colorectal cancer remains unknown. The present study aims to examine the expression level of DBC1 and assess its prognostic value in human colorectal cancer. METHODS: Immunohistochemical staining was performed to detect the expression level of DBC1 in a series of 186 colorectal cancer patients. Immunohistochemical staining results were analyzed and compared statistically with various clinicopathological characters and overall survival. RESULTS: Compared with the corresponding non-tumor tissues, a higher expression level of DBC1 was detected in colorectal cancer (P < 0.01). Tissue microarray analysis revealed that DBC1 expression is significantly associated with tumor histological grade, TNM stage and metastatic status (P < 0.01). Importantly, Kaplan-Meier analysis showed that DBC1 expression is associated with shorter overall survival (P < 0.01). Univariate Cox regression suggested that DBC1 expression, poorly differentiation status and the presence of lymph node metastasis predict shorter overall survival in colorectal cancer (P < 0.05). Multivariate Cox regression analysis indicated that DBC1 acts as an independent prognostic factor in colorectal cancer (P < 0.01). CONCLUSIONS: These results suggest that DBC1 is over-expressed in colorectal cancer and that it might serve as a predictor for selecting patients at high risk of poor prognosis.
Yongguo Zhang; Yong Gu; Sumei Sha; Xiangyun Kong; Hongwu Zhu; Bin Xu; Yijun Li; Kaichun Wu
Related Documents :
16173546 - Use of expert judgment to bound lung cancer risks.
23843146 - Spink1 expression is tightly linked to 6q15- and 5q21-deleted erg-fusion negative prost...
24312366 - Identification of mir-30e* regulation of bmi1 expression mediated by tumor-associated m...
23665506 - Inhibition of mortalin expression reverses cisplatin resistance and attenuates growth o...
11501326 - Playing the waiting game ... the asymptomatic patient with recurrent ovarian cancer det...
25013506 - Pinellia pedatisecta agglutinin-based lectin blot analysis distinguishes between glycos...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-9
Journal Detail:
Title:  International journal of clinical oncology     Volume:  -     ISSN:  1437-7772     ISO Abbreviation:  Int. J. Clin. Oncol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616295     Medline TA:  Int J Clin Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
State Key Laboratory of Cancer Biology, Department of Gastroenterology, Xijing Hospital, The Fourth Military Medical University, 127 Changle Western Road, Xi'an, Shaanxi, 710032, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clinicians' rationale for using a silver dressing: the French OMAg+E observational study.
Next Document:  Degraded DNA may induce discordance of KRAS status between primary colorectal cancer and correspondi...