| D'Amico risk stratification correlates with degree of suspicion of prostate cancer on multiparametric magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 21239006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: We determined whether there is a correlation between D'Amico risk stratification and the degree of suspicion of prostate cancer on multiparametric magnetic resonance imaging based on targeted biopsies done with our electromagnetically tracked magnetic resonance imaging/ultrasound fusion platform. MATERIALS AND METHODS: A total of 101 patients underwent 3 Tesla multiparametric magnetic resonance imaging of the prostate, consisting of T2, dynamic contrast enhanced, diffusion weighted and spectroscopy images in cases suspicious for or with a diagnosis of prostate cancer. All prostate magnetic resonance imaging lesions were then identified and graded by the number of positive modalities, including low-2 or fewer, moderate-3 and high-4 showing suspicion on multiparametric magnetic resonance imaging. The biopsy protocol included standard 12-core biopsy, followed by real-time magnetic resonance imaging/ultrasound fusion targeted biopsies of the suspicious magnetic resonance lesions. Cases and lesions were stratified by the D'Amico risk stratification. RESULTS: In this screening population 90.1% of men had a negative digital rectal examination. Mean±SD age was 62.7±8.3 years and median prostate specific antigen was 5.8 ng/ml. Of the cases 54.5% were positive for cancer on protocol biopsy. Chi-square analysis revealed a statistically significant correlation between magnetic resonance suspicion and D'Amico risk stratification (p<0.0001). Within cluster resampling demonstrated a statistically significant correlation between magnetic resonance suspicion and D'Amico risk stratification for magnetic resonance targeted core biopsies and magnetic resonance lesions (p<0.01) CONCLUSIONS: Our data support the notion that using multiparametric magnetic resonance prostate imaging one may assess the degree of risk associated with magnetic resonance visible lesions in the prostate. |
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Authors:
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Ardeshir R Rastinehad; Angelo A Baccala; Paul H Chung; Juan M Proano; Jochen Kruecker; Sheng Xu; Julia K Locklin; Baris Turkbey; Joanna Shih; Gennady Bratslavsky; W Marston Linehan; Neil D Glossop; Pingkun Yan; Samuel Kadoury; Peter L Choyke; Bradford J Wood; Peter A Pinto |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't Date: 2011-01-15 |
Journal Detail:
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Title: The Journal of urology Volume: 185 ISSN: 1527-3792 ISO Abbreviation: J. Urol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-14 Completed Date: 2011-03-30 Revised Date: 2012-03-07 |
Medline Journal Info:
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Nlm Unique ID: 0376374 Medline TA: J Urol Country: United States |
Other Details:
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Languages: eng Pagination: 815-20 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Urologic Oncology Branch, Molecular Imaging Program, National Cancer Institute, Department of Radiology and Imaging Sciences, National Institutes of Health and Center for Interventional Oncology, Bethesda, Maryland 20892-1107, USA. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Humans Magnetic Resonance Imaging* Male Middle Aged Prospective Studies Prostatic Neoplasms / diagnosis* Risk Assessment / methods |
| Grant Support | |
ID/Acronym/Agency:
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Z01 BC011023-01/BC/NCI NIH HHS; Z01 BC011081-01/BC/NCI NIH HHS; Z01 BC011089-01/BC/NCI NIH HHS; Z01 BC011092-01/BC/NCI NIH HHS; ZIA CL040011-03/CL/CLC NIH HHS; ZID BC011242-02/BC/NCI NIH HHS |
| Comments/Corrections | |
Comment In:
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J Urol. 2011 Mar;185(3):820
[PMID:
21239004
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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