| DAZL is essential for stress granule formation implicated in germ cell survival upon heat stress. | |
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MedLine Citation:
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PMID: 22223682 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Mammalian male germ cells should be maintained below body temperature for proper development. Here, we investigated how male germ cells respond to heat stress. A short exposure of mouse testes to core body temperature induced phosphorylation of eIF2α and the formation of stress granules (SGs) in male germ cells. We observed that DAZL, a germ cell-specific translational regulator, was translocated to SGs upon heat stress. Furthermore, SG assembly activity was significantly diminished in the early male germ cells of Dazl-knockout mice. The DAZL-containing SGs played a protective role against heat stress-induced apoptosis by the sequestration of specific signaling molecules, such as RACK1, and the subsequent blockage of the apoptotic MAPK pathway. Based on these results, we propose that DAZL is an essential component of the SGs, which prevent male germ cells from undergoing apoptosis upon heat stress. |
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Authors:
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Byunghyuk Kim; Howard J Cooke; Kunsoo Rhee |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Development (Cambridge, England) Volume: 139 ISSN: 1477-9129 ISO Abbreviation: Development Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701744 Medline TA: Development Country: England |
Other Details:
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Languages: eng Pagination: 568-78 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, Seoul National University, Seoul 151-747, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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