Document Detail


DASH (Dietary Approaches to Stop Hypertension) diet is effective treatment for stage 1 isolated systolic hypertension.
MedLine Citation:
PMID:  11509468     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Use of the DASH (Dietary Approaches to Stop Hypertension) diet, which is rich in fruits, vegetables, and low-fat dairy foods, significantly lowers blood pressure. Among the 459 participants in the DASH Trial, 72 had stage 1 isolated systolic hypertension (ISH) (systolic blood pressure, 140 to 159 mm Hg; diastolic blood pressure, <90 mm Hg). We examined the blood pressure response in these 72 participants to determine whether the DASH diet is an effective treatment for stage 1 ISH. After a 3-week run-in period on a typical American (control) diet, participants were randomly assigned for 8 weeks to 1 of 3 diets: a continuation of the control diet (n=25), a diet rich in fruits and vegetables (n=24), or the DASH diet (n=23). Sodium content was the same in the 3 diets, and caloric intake was adjusted during the trial to prevent weight change. Blood pressure was measured at baseline and at the end of the 8-week intervention period with standard sphygmomanometry. Use of the DASH diet significantly lowered systolic blood pressure compared with the control diet (-11.2 mm Hg; 95% confidence interval, -6.1 to -16.2 mm Hg; P<0.001) and the fruits/vegetables diet (-8.0 mm Hg; 95% confidence interval, -2.5 to -13.4 mm Hg; P<0.01). Overall, blood pressure in the DASH group fell from 146/85 to 134/82 mm Hg. Similar results were observed with 24-hour ambulatory blood pressure measurements. In the DASH diet group, 18 of 23 participants (78%) reduced their systolic blood pressure to <140 mm Hg, compared with 24% and 50% in the control and fruits/vegetables groups, respectively. Our results indicate that the DASH diet, which is rich in fruits, vegetables, and low-fat dairy foods, is effective as first-line therapy in stage 1 ISH.
Authors:
T J Moore; P R Conlin; J Ard; L P Svetkey
Related Documents :
9017758 - Chronobiometric assessment of autogenic training effects upon blood pressure and heart ...
6407638 - Randomised controlled comparative study of methyldopa and oxprenolol in treatment of hy...
17541328 - Effects of candesartan and lisinopril on the fibrinolytic system in hypertensive patients.
3193818 - Blood pressure load--a better determinant of hypertension.
3060208 - Respiratory system, lung, and chest wall mechanics in guinea pigs.
11410118 - Physiological relationships between central vascular haemodynamics and left ventricular...
Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  38     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-17     Completed Date:  2001-08-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  155-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA. tmoore@bu.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Blood Pressure
Female
Humans
Hypertension / drug therapy*,  physiopathology
Male
Middle Aged
Systole
Grant Support
ID/Acronym/Agency:
HL-02642/HL/NHLBI NIH HHS; HL-50968/HL/NHLBI NIH HHS; HL-50972/HL/NHLBI NIH HHS; HL-50977/HL/NHLBI NIH HHS; HL-50981/HL/NHLBI NIH HHS; HL-50982/HL/NHLBI NIH HHS; RR-00722/RR/NCRR NIH HHS; RR-02635/RR/NCRR NIH HHS
Comments/Corrections
Comment In:
ACP J Club. 2002 Mar-Apr;136(2):48   [PMID:  11874273 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Health literacy: addressing the health and education divide.
Next Document:  Wine polyphenols decrease blood pressure, improve NO vasodilatation, and induce gene expression.