Document Detail


DART-MS as a Preliminary Screening Method for "Herbal Incense": Chemical Analysis of Synthetic Cannabinoids.
MedLine Citation:
PMID:  24313746     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Direct analysis in real time mass spectrometry (DART-MS) served as a method for rapid high-throughput screening of six commercially available "Spice" products, detecting various combinations of five synthetic cannabinoids. Direct analysis in real time is an ambient ionization process that, along with high mass accuracy time-of-flight (TOF)-MS to 0.0001 Da, was employed to establish the presence of cannabinoids. Mass spectra were acquired by simply suspending a small portion of sample between the ion source and the mass spectrometer inlet. The ability to test minute amounts of sample is a major advantage when very limited amounts of evidentiary material are available. In addition, reports are widespread regarding the testing backlogs that now exist because of the large influx of designer drugs. This method circumvents time-consuming sample extraction, derivatization, chromatographic, and other sample preparative steps required for analysis by more conventional mass spectrometric methods. Accordingly, the synthetic cannabinoids AM-2201, JWH-122, JWH-203, JWH-210, and RCS-4 were identified in commercially available herbal Spice products, singly and in tandem, at concentrations within the range of 4-141 mg/g of material. Direct analysis in real time mass spectrometry decreases the time necessary to triage analytical evidence, and therefore, it has the potential to contribute to backlog reduction and more timely criminal prosecution.
Authors:
Ashton D Lesiak; Rabi A Musah; Marek A Domin; Jason R E Shepard
Related Documents :
14871506 - Derivative spectrophotometric and fluorimetric methods for determination of rofecoxib i...
20490306 - Simultaneous spectrophotometric estimation of norfloxacin and ornidazole in tablet dosa...
16959536 - Study of the sensitization of tetradecyl benzyl dimethyl ammonium chloride for the colo...
16019836 - Screening method for the detection of artificial colours in saffron using derivative uv...
18402726 - Photodegradation of crude oil: liquid injection and headspace solid-phase microextracti...
20648676 - Identification and quantification of 30 antipsychotics in blood using lc-ms/ms.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-6
Journal Detail:
Title:  Journal of forensic sciences     Volume:  -     ISSN:  1556-4029     ISO Abbreviation:  J. Forensic Sci.     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-12-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375370     Medline TA:  J Forensic Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 American Academy of Forensic Sciences.
Affiliation:
Department of Chemistry, University at Albany, SUNY, 1400 Washington Ave., Albany, NY 12222.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Adverse effects associated with high-dose olanzapine therapy in patients admitted to inpatient psych...
Next Document:  Underscoring the Influence of Inorganic Chemistry on Nuclear Imaging with Radiometals.