| DANAMI-2: is primary angioplasty superior to thrombolysis in acute MI when the patient has to be transferred to an invasive centre? | |
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MedLine Citation:
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PMID: 12208584 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Primary angioplasty is superior to thrombolysis in acute myocardial infarction when performed in a timely manner but the benefits are unknown when inter-hospital transfer is required for angioplasty. On the 20th March 2002 at the American College of Cardiology 51st Annual Scientific Session, the results of the Danish Multicentre Randomized Trial on Thrombolytic Therapy versus Acute Coronary Angioplasty in Acute Myocardial Infarction (DANAMI-2) were presented. 1,572 patients were randomized to front loaded tPA or angioplasty on presentation within 12 h of acute myocardial infarction; 1,129 from hospitals requiring transfer for up to 3 h for angioplasty. The trial was stopped early since there was a 40% relative reduction in the composite primary end-point of death, disabling stroke or reinfarction within 30 days (absolute reduction 13.7 to 8%, p=0.0003) with primary angioplasty. This appeared to be driven by a significant reduction of reinfarction from 6.3 to 1.6%. Ambulance transfer was shown to be safe but time to angioplasty was approximately 60 min longer than time to thrombolysis. No data are as yet available on the relative infarct sizes or left ventricular function in the two groups. The management of acute myocardial infarction is an area of missed opportunities. Patients present late to hospital, up to 30% of eligible patients do not receive reperfusion therapy and door to needle time is longer than is ideal. Whilst we await the full details of the trial and long term follow-up, we should not forget the challenges of conventional management of acute myocardial infarction. |
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Authors:
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J C C Moon; P R Kalra; A J S Coats |
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Publication Detail:
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Type: Clinical Trial; Editorial; Randomized Controlled Trial |
Journal Detail:
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Title: International journal of cardiology Volume: 85 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-09-04 Completed Date: 2002-12-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 199-201 Citation Subset: IM |
Affiliation:
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Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK. j.moon@rbh.nthames.nhs.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary* Humans Multicenter Studies as Topic Myocardial Infarction / therapy* Patient Transfer* Randomized Controlled Trials as Topic Thrombolytic Therapy* Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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