| DA strain of Theiler's murine encephalomyelitis virus induces demyelination in nude mice. | |
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MedLine Citation:
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PMID: 6732198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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DA strain of Theiler's murine encephalomyelitis virus produces a chronic, progressive demyelinating disease in mice that resembles multiple sclerosis. An immunopathological mechanism for demyelination has been postulated, because there is a brisk immune response with low virus titers at the time of demyelination and because immunosuppression lessens the degree of demyelination. We inoculated Nude mice with DA virus to clarify the role of immune-mediated demyelination. Animals became paralyzed 3 weeks to 2 months after inoculation, usually dying within a week of appearance of signs. Demyelinated foci were present in the spinal cords, with evidence of degenerating myelin around intact axons as well as completely demyelinated, naked axons. Occasional macrophages were present, but none was seen actively stripping intact myelin lamellae. These results suggest that DA virus lytic infection, without a contribution from the T lymphocyte immune system, is sufficient to produce demyelination. It is likely that DA virus demyelination has varying mechanisms that may be active at different times. |
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Authors:
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R P Roos; R Wollmann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of neurology Volume: 15 ISSN: 0364-5134 ISO Abbreviation: Ann. Neurol. Publication Date: 1984 May |
Date Detail:
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Created Date: 1984-07-19 Completed Date: 1984-07-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 494-9 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Demyelinating Diseases / etiology*, pathology Disease Models, Animal* Enterovirus Infections / complications* Maus Elberfeld virus Mice Mice, Inbred BALB C Mice, Inbred Strains Mice, Nude Multiple Sclerosis* Myelin Sheath / ultrastructure |
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