Document Detail

D609 inhibits the proliferation of neural progenitor cells.
MedLine Citation:
PMID:  20568314     Owner:  NLM     Status:  MEDLINE    
We examined the effect of tricyclodecan-9-yl-xanthogenate (D609), a phosphatidylcholine-specific phospholipase C inhibitor, on the proliferation of adult neural progenitor cells in vitro. D609 (100 microM) decreased the proliferation of neural progenitor cells as measured by the proliferation assay, bromodeoxyuridine incorporation, and cell counting without causing cell death. Immunoblot analysis showed a decrease in the expression of cyclin D1 and phosphorylation of retinoblastoma after the incubation of cells with D609. These results suggest that D609 inhibits the proliferation of neural progenitor cells by reducing the cyclin D1 content resulting in decreased phosphorylation of retinoblastoma and subsequent inhibition of cell division.
Haviryaji S G Kalluri; Robert J Dempsey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  21     ISSN:  1473-558X     ISO Abbreviation:  Neuroreport     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-21     Completed Date:  2010-10-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  700-3     Citation Subset:  IM    
Department of Neurological Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA.
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MeSH Terms
Adult Stem Cells / drug effects*,  physiology
Bridged Compounds / pharmacology*
Cell Count
Cell Death / drug effects
Cell Proliferation / drug effects*
Cells, Cultured
Cyclin D1 / metabolism
Neurogenesis / drug effects*
Neurons / drug effects*,  physiology
Phosphodiesterase Inhibitors / pharmacology*
Rats, Inbred SHR
Retinoblastoma Protein / metabolism
Thiones / pharmacology*
Type C Phospholipases / antagonists & inhibitors
Reg. No./Substance:
0/Bridged Compounds; 0/Phosphodiesterase Inhibitors; 0/Retinoblastoma Protein; 0/Thiones; 136601-57-5/Cyclin D1; 59-14-3/Bromodeoxyuridine; 83373-60-8/tricyclodecane-9-yl-xanthogenate; EC 3.1.4.-/Type C Phospholipases

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