Document Detail

D4 receptor deficiency in mice has limited effects on impulsivity and novelty seeking.
MedLine Citation:
PMID:  18456309     Owner:  NLM     Status:  MEDLINE    
Alleles of the human dopamine D(4) receptor (D(4)R) gene (DRD4.7) have repeatedly been found to correlate with novelty seeking, substance abuse, pathological gambling, and attention-deficit hyperactivity disorder (ADHD). If these various psychopathologies are a result of attenuated D(4)R-mediated signaling, mice lacking D(4)Rs (D(4)KO) should be more impulsive than wild-type (WT) mice and exhibit more novelty seeking. However, in our study, D(4)KO and WT mice showed similar levels of impulsivity as measured by delay discounting performance and response inhibition on a Go/No-go test, suggesting that D(4)R-mediated signaling may not affect impulsivity. D(4)KO mice were more active than WT mice in the first 5 min of a novel open field test, suggesting greater novelty seeking. For both genotypes, more impulsive mice habituated less in the novel open field. These data suggest that the absence of D(4)Rs is not sufficient to cause psychopathologies associated with heightened impulsivity and novelty seeking.
C M Helms; N R Gubner; C J Wilhelm; S H Mitchell; D K Grandy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-03-28
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  90     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-06-09     Completed Date:  2008-08-25     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  387-93     Citation Subset:  IM    
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MeSH Terms
Exploratory Behavior / physiology*
Impulsive Behavior / genetics*,  psychology*
Mice, Inbred C57BL
Mice, Knockout
Motor Activity / physiology
Polymorphism, Genetic
Psychomotor Performance / physiology
Receptors, Dopamine D4 / deficiency*,  genetics
Grant Support
5 T32-AA07468/AA/NIAAA NIH HHS; F31 MH070219-03/MH/NIMH NIH HHS; MH070219/MH/NIMH NIH HHS; MH67497/MH/NIMH NIH HHS; R01 DA016727/DA/NIDA NIH HHS; R01 DA016727-04/DA/NIDA NIH HHS; R01 MH067497-05/MH/NIMH NIH HHS; T32 AA007468/AA/NIAAA NIH HHS; T32 AA007468-21/AA/NIAAA NIH HHS
Reg. No./Substance:
137750-34-6/Receptors, Dopamine D4

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