Document Detail

A D2 antagonist enhances the rewarding and priming effects of a gambling episode in pathological gamblers.
MedLine Citation:
PMID:  17203013     Owner:  NLM     Status:  MEDLINE    
Previous research indicated shared neurochemical substrates for gambling and psychostimulant reward. This suggests that dopamine substrates may directly govern the reinforcement process in pathological gambling. To investigate this issue, the present study assessed the effects of the relatively selective dopamine D2 antagonist, haloperidol (3 mg, oral) on responses to actual gambling (15 min on a slot machine) in 20 non-comorbid pathological gamblers and 18 non-gambler controls in a placebo-controlled, double-blind, counterbalanced design. In gamblers, haloperidol significantly increased self-reported rewarding effects of gambling, post-game priming of desire to gamble, facilitation of reading speed to Gambling words, and gambling-induced elevation in blood pressure. In controls, haloperidol augmented gambling-induced elevation in blood pressure, but had no effect on other indices. The findings provide direct experimental evidence that the D2 substrate modulates gambling reinforcement in pathological gamblers.
Martin Zack; Constantine X Poulos
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-01-03
Journal Detail:
Title:  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology     Volume:  32     ISSN:  0893-133X     ISO Abbreviation:  Neuropsychopharmacology     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-19     Completed Date:  2007-09-26     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8904907     Medline TA:  Neuropsychopharmacology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1678-86     Citation Subset:  IM    
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MeSH Terms
Analysis of Variance
Blood Pressure / drug effects
Dopamine Antagonists / administration & dosage,  adverse effects*
Double-Blind Method
Gambling / psychology*
Haloperidol / administration & dosage,  adverse effects*
Middle Aged
Neuropsychological Tests
Pain Measurement
Psychiatric Status Rating Scales
Reaction Time / drug effects
Reg. No./Substance:
0/Dopamine Antagonists; J6292F8L3D/Haloperidol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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