| A D2 antagonist enhances the rewarding and priming effects of a gambling episode in pathological gamblers. | |
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MedLine Citation:
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PMID: 17203013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous research indicated shared neurochemical substrates for gambling and psychostimulant reward. This suggests that dopamine substrates may directly govern the reinforcement process in pathological gambling. To investigate this issue, the present study assessed the effects of the relatively selective dopamine D2 antagonist, haloperidol (3 mg, oral) on responses to actual gambling (15 min on a slot machine) in 20 non-comorbid pathological gamblers and 18 non-gambler controls in a placebo-controlled, double-blind, counterbalanced design. In gamblers, haloperidol significantly increased self-reported rewarding effects of gambling, post-game priming of desire to gamble, facilitation of reading speed to Gambling words, and gambling-induced elevation in blood pressure. In controls, haloperidol augmented gambling-induced elevation in blood pressure, but had no effect on other indices. The findings provide direct experimental evidence that the D2 substrate modulates gambling reinforcement in pathological gamblers. |
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Authors:
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Martin Zack; Constantine X Poulos |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2007-01-03 |
Journal Detail:
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Title: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Volume: 32 ISSN: 0893-133X ISO Abbreviation: Neuropsychopharmacology Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-19 Completed Date: 2007-09-26 Revised Date: 2011-05-18 |
Medline Journal Info:
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Nlm Unique ID: 8904907 Medline TA: Neuropsychopharmacology Country: United States |
Other Details:
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Languages: eng Pagination: 1678-86 Citation Subset: IM |
Affiliation:
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Clinical Neuroscience Section, Centre for Addiction and Mental Health, Toronto, ON, Canada. martin_zack@camh.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Blood Pressure / drug effects Dopamine Antagonists / administration & dosage, adverse effects* Double-Blind Method Female Gambling / psychology* Haloperidol / administration & dosage, adverse effects* Humans Male Middle Aged Motivation Neuropsychological Tests Pain Measurement Psychiatric Status Rating Scales Reaction Time / drug effects Reward* Semantics |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Antagonists; 52-86-8/Haloperidol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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