Document Detail


D19S51 is closely linked with and maps distal to the myotonic dystrophy locus on 19q.
MedLine Citation:
PMID:  1928101     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent genetic linkage studies have mapped the myotonic dystrophy (DM) locus to 19q13.3. All closely linked DM markers identified to date have been located on the centromeric side of the disease locus, with a relatively large genetic interval (9 cM) observed between the nearest distal marker and DM. We show here that the recently described marker p134C is tightly linked to DM (peak lod score 35.8 at peak recombination fraction .006) and confirm the previous suggestion that the p134C locus, D19S51 maps distal to the disease locus. D19S51 and the closest proximal flanking loci, ERCC1 and D19S115 (pE0.8), define a small genetic interval of less than 2 cM that contains the DM locus.
Authors:
C Tsilfidis; A E MacKenzie; G Shutler; S Leblond; J Bailly; K Johnson; R Williamson; J Siegel-Bartelt; R G Korneluk; P Shelbourne
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of human genetics     Volume:  49     ISSN:  0002-9297     ISO Abbreviation:  Am. J. Hum. Genet.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1991-11-21     Completed Date:  1991-11-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370475     Medline TA:  Am J Hum Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  961-5     Citation Subset:  IM    
Affiliation:
Division of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Canada.
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MeSH Terms
Descriptor/Qualifier:
Chromosome Mapping
Chromosomes, Human, Pair 19*
Female
Genetic Markers*
Humans
Linkage (Genetics)
Male
Muscular Dystrophies / genetics*
Pedigree
Chemical
Reg. No./Substance:
0/Genetic Markers
Comments/Corrections
Erratum In:
Am J Hum Genet 1992 Mar;50(3):659

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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