Document Detail


D1 and D2 dopamine receptors in perinatal and adult basal ganglia.
MedLine Citation:
PMID:  9167195     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is reason to believe that dopamine is important in developmental programs of the basal ganglia, brain nuclei implicated in motor and cognitive processing. Dopamine exerts effects through dopamine receptors, which are predominantly of the D1 and D2 subtypes in the basal ganglia. Cocaine acts as a stimulant of dopamine receptors and may cause long-term abnormalities in children exposed in utero. Dopamine receptor (primarily D1) stimulation has been linked to gene regulation. Therefore, D1 and D2 receptor densities in perinatal and adult striatum and globus pallidus were examined using quantitative autoradiography. The most striking finding was that pallidal D1 receptor densities were 7-15 times greater in the perinatal cases than in the adult. Pallidal D2 receptor densities were similar at both ages. In both the adult and perinatal striatum, D2 receptor densities were greater in the putamen than in the caudate, and both D1 and D2 receptor densities were modestly enriched in caudate striosomes compared with the matrix. In both caudate and putamen, perinatal D1 receptor levels were within the adult range, whereas D2 receptor levels were only 50% of adult values. The development of D1 and D2 receptors appears to vary across the major subdivisions of the human basal ganglia. The facts that we found such extremely high levels of D1 receptors in the perinatal pallidum, and that D1 receptor activation influences gene regulation, suggest that the globus pallidus could be particularly susceptible to long-term changes with perinatal exposure to cocaine and other D1 receptor agonists or antagonists.
Authors:
S J Boyson; C E Adams
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  41     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-07-18     Completed Date:  1997-07-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  822-31     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Aging / metabolism*
Animals
Animals, Newborn
Basal Ganglia / growth & development,  metabolism*
Caudate Nucleus / growth & development,  metabolism
Corpus Striatum / growth & development,  metabolism
Globus Pallidus / growth & development,  metabolism
Humans
Infant
Infant, Newborn
Organ Specificity
Putamen / growth & development,  metabolism
Receptors, Dopamine D1 / metabolism*
Receptors, Dopamine D2 / metabolism*
Grant Support
ID/Acronym/Agency:
NS01195/NS/NINDS NIH HHS; NS09199/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Dopamine D1; 0/Receptors, Dopamine D2

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