| D-pinitol attenuates the impaired activities of hepatic key enzymes in carbohydrate metabolism of streptozotocin-induced diabetic rats. | |
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MedLine Citation:
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PMID: 20037188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During diabetes mellitus, endogenous hepatic glucose production is increased as a result of impaired activities of the key enzymes of carbohydrate metabolism, which leads to the condition known as hyperglycemia. D-pinitol, a bioactive constituent isolated from soybeans, has been shown to reduce hyperglycemia in experimental diabetes. We therefore designed this study to investigate the effect of oral administration of D-pinitol (50 mg/kg b. w. for 30 days) on the activities of key enzymes in carbohydrate and glycogen metabolism in the liver tissues of streptozotocin-induced diabetic rats. The efficacy was compared with glyclazide, a standard hypoglycemic drug. Oral administration of D-pinitol to diabetic group of rats showed a marked decrease in the levels of blood glucose, glycosylated hemoglobin and an increase in plasma insulin and body weight. The activities of the hepatic enzymes such as hexokinase, pyruvate kinase, glucose-6-phosphate dehydrogenase, glycogen synthase and hepatic glycogen content were significantly (p < 0.05) increased whereas the activities of glucose-6-phosphatase, fructose-1,6-bisphosphatase, lactate dehydrogenase and glycogen phosphorylase were significantly (p < 0.05) decreased in diabetic rats treated with D-pinitol. The results suggest that alterations in the activities of key metabolic enzymes of carbohydrate metabolism could be one of the biochemical rationale by which D-pinitol attenuates the hyperglycemic effect in diabetic rats. |
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Authors:
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Selvaraj Sivakumar; Sorimuthu P Subramanian |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: General physiology and biophysics Volume: 28 ISSN: 0231-5882 ISO Abbreviation: Gen. Physiol. Biophys. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-12-28 Completed Date: 2010-03-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8400604 Medline TA: Gen Physiol Biophys Country: Slovakia |
Other Details:
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Languages: eng Pagination: 233-41 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, University of Madras, Tamilnadu, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight / drug effects Carbohydrate Metabolism / drug effects* Diabetes Mellitus, Experimental / drug therapy*, enzymology, metabolism Gliclazide / pharmacology Glucose Tolerance Test Glycogen / metabolism Glycogen Phosphorylase / metabolism Glycogen Synthase / metabolism Hypoglycemic Agents / administration & dosage, pharmacology* Inositol / administration & dosage, analogs & derivatives*, pharmacology Liver / drug effects*, enzymology, metabolism Male Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Hypoglycemic Agents; 21187-98-4/Gliclazide; 484-68-4/pinitol; 6917-35-7/Inositol; 9005-79-2/Glycogen; EC 2.4.1.-/Glycogen Phosphorylase; EC 2.4.1.11/Glycogen Synthase |
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