| D-dimer and thrombin-antithrombin III complex levels uncorrelated with phlebographic findings in 11 total knee replacement patients. | |
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MedLine Citation:
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PMID: 2193559 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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D-dimer and thrombin-antithrombin III complex (TAT) were assayed in 11 patients at various times pre- and post-operatively in order to determine the possible value of these parameters in screening for thromboembolic complications. Phlebography revealed distal thrombosis in 6 of the 11 patients. The D-dimer level, already elevated before surgery, increased at day 1 and remained high at days 5 and 10. Two methods were used for the assays and showed strongly correlated results. The TAT level increased at day 1 and then progressively returned toward basal values. No difference was observed at any time between patients with or without thrombosis. The results in surgical patients undergoing knee replacement suggest that neither D-dimer nor TAT assays are valid screening procedures for post-operative DVT. Nevertheless, in view of the small number of patient studied, further work is required to confirm these results. |
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Authors:
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D De Prost; V Ollivier; P Vie; R Benacerraf; J Duparc; A Khoury |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annales de biologie clinique Volume: 48 ISSN: 0003-3898 ISO Abbreviation: Ann. Biol. Clin. (Paris) Publication Date: 1990 |
Date Detail:
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Created Date: 1990-08-02 Completed Date: 1990-08-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2984690R Medline TA: Ann Biol Clin (Paris) Country: FRANCE |
Other Details:
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Languages: eng Pagination: 235-8 Citation Subset: IM |
Affiliation:
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Service d'Hématologie et d'Immunologie Biologiques, Centre Hospitalo-Universitaire X. Bichat, Paris. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antithrombin III / analysis* Biological Markers Female Fibrin Fibrinogen Degradation Products / analysis* Humans Knee Prosthesis* / adverse effects Male Middle Aged Peptide Hydrolases / analysis* Phlebography Postoperative Period Reagent Kits, Diagnostic Thrombophlebitis / prevention & control Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Fibrin Fibrinogen Degradation Products; 0/Reagent Kits, Diagnostic; 0/antithrombin III-protease complex; 0/fibrin fragment D; 9000-94-6/Antithrombin III; EC 3.4.-/Peptide Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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