Document Detail

D-dimer strategy in thrombosis exclusion--a gold standard study in 100 patients suspected of deep venous thrombosis or pulmonary embolism: 8 DD methods compared.
MedLine Citation:
PMID:  9459318     Owner:  NLM     Status:  MEDLINE    
DD are now recognized as a valuable tool to screen patients suspected of deep venous thrombosis or pulmonary embolism before carrying out a gold standard radiologic examination. The newest methods available claim to be able to ascertain the absence of thrombosis, but they have yet to prove their efficiency. We compared the performances of 3 reference ELISA methods (D-DI Asserachrom Stago, D-dimer Enzygnost Behring and Dimertest GOLD EIA Agen), 5 recent rapid methods (VIDAS D-Dimer bioMérieux, Instant IA Stago, Simplired Agen, Nycocard D-dimer Nycomed and Accuclot D-Dimer Sigma Diagnostics) and two routine latex methods (Dimertest American Diagnostica and FDP-Slidex bioMérieux) in 100 patients. One of the rapid quantitative methods was demonstrated to have a level of efficiency comparable to that of ELISA methods. Finally, the cost and efficiency of different strategies were evaluated, the association of a routine latex method with the VIDAS D-Dimer bioMérieux being proven to be the most efficient.
G Freyburger; H Trillaud; S Labrouche; P Gauthier; S Javorschi; P Bernard; N Grenier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  79     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-03-12     Completed Date:  1998-03-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  32-7     Citation Subset:  IM    
Laboratoire d'Hématologie, Hôpital Pellegrin, Université Bxll, Bordeaux, France.
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MeSH Terms
Diagnosis, Differential
Fibrin Fibrinogen Degradation Products / analysis*
Laboratory Techniques and Procedures
Mass Screening / methods*
Middle Aged
Predictive Value of Tests
Pulmonary Embolism / blood,  diagnosis*
Reference Standards
Thrombophlebitis / blood,  diagnosis*,  radiography
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/fibrin fragment D

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