| D-dimer level is associated with the extent of pulmonary embolism. | |
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MedLine Citation:
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PMID: 17030057 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Our aim was to study the association between the level of D-dimer and the severity of pulmonary embolism (PE) as determined by various biochemical and radiological prognostic markers in order to investigate the potential value of D-dimer as a prognostic marker for the severity of PE. PATIENTS AND METHODS: PE was diagnosed in 100 consecutive out-patients by multi-detector computerized tomography. One patient was excluded and the final cohort consisted of 99 patients. Pulmonary Artery Obstruction Index (PAOI) and Right Ventricular/Left Ventricular (RV/LV) ratio were assessed. RESULTS: The median value for D-dimer was 5.0 mg/L (inter-quartile range: 1.8, 12.2). There was a significant association between log D-dimer, and between log RV/LV (r=0.45), log PAOI (r=0.5), and PaO(2) (r=0.40). The multivariate analysis showed an increased association between log D-dimer and between log RV/LV ratio (r=0.54) and log PAOI (r=0.52) after adjusting for age, gender and for the duration of symptoms. Significant association was found between the level of D-dimer and the most proximal level of PE (p<0.0005). There was a significant dose-response relationship between the level D-dimer and between Troponin-T and the frequency of thrombolysis (p<0.0005). In the subgroup of patients with D-Dimer over the upper quartile (>12.2), 12 (67%) patients had elevated Troponin-T and 8 (32%) patients received thrombolysis, compared to 1 (5%) patient with elevated Troponin-T and none treated with thrombolysis in the subgroup of patients with D-dimer<lower quartile. CONCLUSIONS: We have shown that the level of D-dimer is related to the severity of PE assessed by various radiological, biochemical and clinical markers and might have a potential value as prognostic marker for the severity of PE. |
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Authors:
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W Ghanima; M Abdelnoor; L O Holmen; B E Nielssen; S Ross; P M Sandset |
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Publication Detail:
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Type: Journal Article Date: 2006-10-09 |
Journal Detail:
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Title: Thrombosis research Volume: 120 ISSN: 0049-3848 ISO Abbreviation: Thromb. Res. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-05-21 Completed Date: 2007-07-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0326377 Medline TA: Thromb Res Country: United States |
Other Details:
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Languages: eng Pagination: 281-8 Citation Subset: IM |
Affiliation:
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Østfold Hospital Trust in Fredrikstad, Department of Medicine, Fredrikstad, Norway. waleed.ghanima@so-hf.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood Cohort Studies Female Fibrin Fibrinogen Degradation Products / metabolism* Humans Male Middle Aged Prognosis Pulmonary Embolism / blood*, radiography Tomography, X-Ray Computed Troponin T / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Fibrin Fibrinogen Degradation Products; 0/Troponin T; 0/fibrin fragment D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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