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D-dimer in preeclampsia: review and meta-analysis.
MedLine Citation:
PMID:  22922438     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Preeclampsia is a multifactorial disease characterized by high blood pressure and proteinuria after the 20th week of pregnancy. Preeclampsia is associated with microvasculature fibrin deposition and maternal organ dysfunction. D-dimer (D-Di) has been used as a marker of production/degradation of fibrin in vivo. D-Di has emerged as a useful diagnostic tool for thrombotic conditions because its plasma concentration has a high negative predictive value for venous thromboembolism. The aim of this study was to evaluate publications that assessed plasma D-Di in preeclampsia and normotensive pregnant subjects to define its diagnostic value. A total of 194 publications were identified. Following the exclusion process, seven studies were in accordance with the pre-defined eligibility criteria. This systematic review was performed with methodologic accuracy, including a careful definition of preeclampsia and a high sensitivity literature search strategy. Quality of the included studies was assessed in accordance with widely accepted literature recommendations. Our meta-analysis indicates that increased plasma D-Di is associated with preeclampsia in the third trimester of gestation vs normotensive pregnant subjects. These preliminary findings in this select group of patients clearly highlight the need for additional comprehensive studies throughout pregnancy, including the establishment of an appropriate cut-off, in order to fully elucidate the diagnostic/prognostic role of D-Di in preeclampsia.
Authors:
Melina de Barros Pinheiro; Daniela Rezende Garcia Junqueira; Fernanda Fonseca Coelho; Letícia G Freitas; Maria G Carvalho; Karina Braga Gomes; Luci Maria Sant'ana Dusse
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-23
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  -     ISSN:  1873-3492     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
Department of Clinical and Toxicological Analysis, Faculty of Pharmacy- Universidade Federal de Minas Gerais/Brazil; School of Medicine - Universidade Federal de São João Del Rei/Brazil.
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