Document Detail


D-dimer in acute pancreatitis: a new approach for an early assessment of organ failure.
MedLine Citation:
PMID:  19436232     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Studies on the clinical value of parameters of hemostasis in predicting pancreatitis-associated complications are still scarce. The aim of this prospective study was to identify the useful hemostatic markers for accurate determination of the subsequent development of organ failure (OF) during the very early course of acute pancreatitis (AP). METHODS: In 91 consecutive primarily admitted patients with AP, prothrombin time, activated partial thromboplastin time, fibrinogen, antithrombin III, protein C, plasminogen activator inhibitor 1, D-dimer, and plasminogen were measured in plasma within the first 24 hours of admission and 24 hours thereafter. Two study groups comprising 24 patients with OF and 67 patients without OF were compared. RESULTS: Levels of prothrombin time, fibrinogen, and D-dimer on admission were significantly different between the OF and non-OF groups, and all these parameters plus antithrombin III were significantly different 24 hours later. A D-dimer value of 414.00 microg/L on admission was the best cutoff value in predicting the development of OF with sensitivity, specificity, and positive and negative predictive values of 90%, 89%, 75%, and 96%, respectively. CONCLUSIONS: Measurement of plasma levels of D-dimer on the admission is an accurate method for the identification of patients who will develop OF in the further course of AP.
Authors:
Dejan Radenkovic; Djordje Bajec; Nenad Ivancevic; Natasa Milic; Vesna Bumbasirevic; Vasilije Jeremic; Vladimir Djukic; Branislava Stefanovic; Branislav Stefanovic; Gorica Milosevic-Zbutega; Pavle Gregoric
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pancreas     Volume:  38     ISSN:  1536-4828     ISO Abbreviation:  Pancreas     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-29     Completed Date:  2009-11-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8608542     Medline TA:  Pancreas     Country:  United States    
Other Details:
Languages:  eng     Pagination:  655-60     Citation Subset:  IM    
Affiliation:
Center for Emergency Surgery, School of Medicine, Surgical Department, University of Belgrade, Belgrade, Serbia. dejanr@sbb.co.yu
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Aged
Biological Markers / blood
Female
Fibrin Fibrinogen Degradation Products / metabolism*
Hemostasis
Humans
Male
Middle Aged
Multiple Organ Failure / blood*,  etiology*
Multivariate Analysis
Pancreatitis / blood*,  complications*
Prospective Studies
ROC Curve
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Fibrin Fibrinogen Degradation Products; 0/fibrin fragment D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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