Document Detail

Is D-dimer helpful in evaluating stroke patients? A systematic review.
MedLine Citation:
PMID:  18705677     Owner:  NLM     Status:  MEDLINE    
D-dimer (DD) is a fibrin degradation product present in negligible amounts in healthy individuals, but in thrombotic/fibrinolytic conditions substantially increases in plasma. Over the last two decades numerous studies have explored whether DD measurements would help stroke clinicians. An easy, reliable, and inexpensive test for stroke diagnosis, determination of stroke subtype, severity, prognosis, and recurrence risk is being sought. We searched the database, of studies indexed in English on MEDLINE, using the keywords 'cerebral venous thrombosis, D-dimer, deep vein thrombosis, intracerebral hemorrhage, ischemic stroke, outcome, prognosis, and subarachnoid hemorrhage' for relevant studies. Here, we systematically review current evidence on plasma DD levels in patients with ischemic and hemorrhagic strokes, transient ischemic attacks, and cerebral venous thrombosis. Numerous studies showed that patients with various strokes and stroke-related diseases had acutely increased plasma DD levels. Plasma DD levels, however, are neither sensitive nor specific enough to be utilized in stroke diagnostics and cannot replace either clinical or radiological evaluation. Regarding prediction of patient outcome, good clinical evaluation is clearly superior to DD testing.
E Haapaniemi; T Tatlisumak
Related Documents :
18776067 - Estimating the minimal clinically important difference of the stroke rehabilitation ass...
20402757 - The i/d polymorphism of the ace1 gene is not associated with ischaemic stroke in spanis...
10512247 - Comparison of transcranial color-coded duplex sonography and cranial ct measurements fo...
10711777 - Hemorheological disturbances and characteristic parameters in patients with cerebrovasc...
7782037 - Exocrine pancreatic function after recovery from necrotizing pancreatitis.
20682677 - Association of bone morphogenetic proteins with spinal fusion in ankylosing spondylitis.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-08-14
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  119     ISSN:  1600-0404     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-03     Completed Date:  2009-04-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  141-50     Citation Subset:  IM    
Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Biological Markers
Blood Coagulation Tests
Diagnostic Imaging
Disease Progression
Fibrin Fibrinogen Degradation Products / analysis*
Middle Aged
Predictive Value of Tests
Risk Assessment
Sensitivity and Specificity
Stroke / blood*,  classification,  diagnosis,  prevention & control
Thromboembolism / blood,  diagnosis
Thrombophilia / blood
Reg. No./Substance:
0/Biological Markers; 0/Fibrin Fibrinogen Degradation Products; 0/fibrin fragment D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Oxcarbazepine treatment in male epilepsy patients improves pre-existing sexual dysfunction.
Next Document:  Cognitive effects of memantine in postmenopausal women at risk of dementia: a pilot study.