Document Detail

Is D-dimer helpful in evaluating stroke patients? A systematic review.
MedLine Citation:
PMID:  18705677     Owner:  NLM     Status:  MEDLINE    
D-dimer (DD) is a fibrin degradation product present in negligible amounts in healthy individuals, but in thrombotic/fibrinolytic conditions substantially increases in plasma. Over the last two decades numerous studies have explored whether DD measurements would help stroke clinicians. An easy, reliable, and inexpensive test for stroke diagnosis, determination of stroke subtype, severity, prognosis, and recurrence risk is being sought. We searched the database, of studies indexed in English on MEDLINE, using the keywords 'cerebral venous thrombosis, D-dimer, deep vein thrombosis, intracerebral hemorrhage, ischemic stroke, outcome, prognosis, and subarachnoid hemorrhage' for relevant studies. Here, we systematically review current evidence on plasma DD levels in patients with ischemic and hemorrhagic strokes, transient ischemic attacks, and cerebral venous thrombosis. Numerous studies showed that patients with various strokes and stroke-related diseases had acutely increased plasma DD levels. Plasma DD levels, however, are neither sensitive nor specific enough to be utilized in stroke diagnostics and cannot replace either clinical or radiological evaluation. Regarding prediction of patient outcome, good clinical evaluation is clearly superior to DD testing.
E Haapaniemi; T Tatlisumak
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-08-14
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  119     ISSN:  1600-0404     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-03     Completed Date:  2009-04-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  141-50     Citation Subset:  IM    
Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
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MeSH Terms
Aged, 80 and over
Biological Markers
Blood Coagulation Tests
Diagnostic Imaging
Disease Progression
Fibrin Fibrinogen Degradation Products / analysis*
Middle Aged
Predictive Value of Tests
Risk Assessment
Sensitivity and Specificity
Stroke / blood*,  classification,  diagnosis,  prevention & control
Thromboembolism / blood,  diagnosis
Thrombophilia / blood
Reg. No./Substance:
0/Biological Markers; 0/Fibrin Fibrinogen Degradation Products; 0/fibrin fragment D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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