| D-dimer assay for deep vein thrombosis: its role with colour Doppler sonography. | |
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MedLine Citation:
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PMID: 10924375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To evaluate the role of a negative D-dimer assay in the initial management of patients with clinically suspected deep venous thrombosis (DVT), using colour Doppler ultrasound as the primary diagnostic technique. MATERIALS AND METHODS: A double-blind prospective trial was performed on 143 patients with clinically suspected DVT. All patients underwent a D-dimer assay prior to anticoagulant therapy. DVT was confirmed or excluded by diagnostic colour Doppler ultrasound within 24 h of presentation. RESULTS: In nearly one-third of the cases (31.8%), Doppler ultrasound was positive. The D-dimer assay demonstrated a sensitivity of 97.7% with only one false-negative, but the specificity was low at 48.9% with 45 false-positive results. The positive predictive value for D-dimer assay was 48.8%, whilst the important negative predictive value was 98%. CONCLUSION: If D-dimer was used to screen for DVT, and patients with negative results were not imaged, then the imaging workload could be reduced by 35%. In this study one small calf vein thrombus would have been missed by adopting this practice.Bradley, M. (2000). Clinical Radiology 55, 525-527. |
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Authors:
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M Bradley; J Bladon; H Barker |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Clinical radiology Volume: 55 ISSN: 0009-9260 ISO Abbreviation: Clin Radiol Publication Date: 2000 Jul |
Date Detail:
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Created Date: 2000-08-31 Completed Date: 2000-08-31 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1306016 Medline TA: Clin Radiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 525-7 Citation Subset: IM |
Copyright Information:
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Copyright 2000 The Royal College of Radiologists. |
Affiliation:
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Departments of Clinical Radiology and Haematology, Rotherham Hospital, Rotherham, U.K. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Double-Blind Method Enzyme-Linked Immunosorbent Assay False Negative Reactions False Positive Reactions Female Fibrin Fibrinogen Degradation Products / analysis Humans Leg / blood supply* Male Middle Aged Prospective Studies Sensitivity and Specificity Ultrasonography, Doppler, Color / methods Venous Thrombosis / blood, ultrasonography* |
| Chemical | |
Reg. No./Substance:
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0/Fibrin Fibrinogen Degradation Products; 0/fibrin fragment D |
| Comments/Corrections | |
Comment In:
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Clin Radiol. 2001 Aug;56(8):689
[PMID:
11467878
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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