| D-dimer and BNP levels in acute aortic dissection. | |
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MedLine Citation:
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PMID: 17234284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Early diagnosis and treatment are pivotal for patients with acute aortic dissection (AAD). D-dimer is a rule-out diagnostic test for pulmonary embolism but there is evidence that it may also be applicable to AAD. We evaluated plasma D-dimer, white cell blood count (WBC), C-reactive protein (CRP) and N-terminal pro-B-type natriuretic peptide (BNP) in 18 consecutive patients with established AAD, 21 consecutive patients with dilated ascending aortas scheduled for elective surgery and 8 normal subjects. Patients with AAD had significantly higher elevated D-dimer, compared to chronic aneurysms and normal controls (p<0.0001). D-dimer level higher than 700 ng/ml had a sensitivity of 94% and specificity of 59% for diagnosis of AAD. The WBC count was also significantly increased compared to the other groups (p<0.01). CRP and BNP values were significantly higher compared to normal controls but these parameters did not distinguish between AAD and chronic aneurysms. D-dimer can be used as a 'rule-out' test in patients with suspected AAD and seems useful in the discrimination between AAD and chronic uncomplicated aneurysms, unlike CRP and BNP plasma levels. |
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Authors:
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Eftihia Sbarouni; Panagiota Georgiadou; Aikaterini Marathias; Stefanos Geroulanos; Dimitrios Th Kremastinos |
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Publication Detail:
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Type: Letter Date: 2007-01-17 |
Journal Detail:
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Title: International journal of cardiology Volume: 122 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-16 Completed Date: 2007-11-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 170-2 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Acute-Phase Reaction / blood Adolescent Adult Aged Aneurysm, Dissecting / blood* Aortic Aneurysm / blood* C-Reactive Protein / analysis Chronic Disease Female Fibrin Fibrinogen Degradation Products / analysis* Humans Leukocyte Count Male Middle Aged Natriuretic Peptide, Brain / blood* Peptide Fragments / blood* Prospective Studies Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Fibrin Fibrinogen Degradation Products; 0/Peptide Fragments; 0/fibrin fragment D; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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