| D-cycloserine, a modulator of the N-methyl-D-aspartate receptor, improves spatial learning in rats treated with muscarinic antagonist. | |
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MedLine Citation:
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PMID: 1491793 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The results of the present study indicate that D-cycloserine, a partial agonist at the glycine binding site, which is a positive modulation site of the N-methyl-D-aspartate receptor, could improve dose dependently the acquisition of a water maze task in rats treated with scopolamine, a muscarinic antagonist. The low to moderate doses of D-cycloserine which improved learning did not affect swimming speed in scopolamine-treated rats. The higher dose did not improve learning, but it increased swimming speed in scopolamine-treated rats. These results show a dissociation between impaired acquisition and abnormal behavioral activity in scopolamine-treated rats in the water maze task. Furthermore, the present results suggest that D-cycloserine can act as a cognitive enhancer at the appropriate doses. |
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Authors:
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J Sirviö; T Ekonsalo; P Riekkinen; H Lahtinen; P Riekkinen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience letters Volume: 146 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1992 Nov |
Date Detail:
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Created Date: 1993-03-02 Completed Date: 1993-03-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 215-8 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Kuopio, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amnesia
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chemically induced,
prevention & control Animals Cycloserine / pharmacology* Learning / drug effects* Male Parasympatholytics / pharmacology* Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors* Scopolamine / pharmacology Space Perception / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Parasympatholytics; 0/Receptors, N-Methyl-D-Aspartate; 51-34-3/Scopolamine; 68-41-7/Cycloserine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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