Document Detail

D-aspartate and reproductive activity in sheep.
MedLine Citation:
PMID:  16203031     Owner:  NLM     Status:  MEDLINE    
D-aspartic acid (D-Asp) has been isolated from neuroendocrine tissues of many invertebrates and vertebrates. Recently, it has been demonstrated that this D-amino acid may be converted to N-methyl-D-aspartic acid (NMDA), a neuromodulator associated with sexual activity. In this study, we determined D-Asp and NMDA concentrations in endocrine glands and other tissues in ewes after D-Asp administration and in controls. We also evaluated the effects of d-Asp administration on the reproductive activity of ewes by determining either progesterone concentrations or LH pulses in the presence or absence of estradiol benzoate. The pineal gland showed the highest natural content of D-Asp (1.47+/-0.22 micromol/g tissue), whereas the pituitary gland had the highest capability to store d-Asp, with a peak value (9.7+/-0.81 micromol/g tissue) 6 h after its administration. NMDA increased sharply 12 h following D-Asp administration, reaching values three times higher than the baseline in both the pituitary and brain. D-Asp was quickly adsorbed after subcutaneous administration, with a peak in plasma levels 2 h after administration and a return to baseline values after 6 h. D-Asp administration achieved a significant (P < 0.001) increase in LH values with respect to estradiol or estradiol + D-Asp treatments. d-Asp treatment once or twice a week did not successfully drive acyclic ewes into reproductive activity. In conclusion, the results obtained in this study demonstrated that D-Asp is endogenously present in sheep tissues and electively stored in endocrine glands and brain after its administration. NMDA and LH increase following D-Asp administration suggesting a role of this D-amino acid in the reproductive activity of sheep.
R Boni; R Santillo; G Macchia; P Spinelli; G Ferrandino; A D'Aniello
Publication Detail:
Type:  Journal Article     Date:  2005-10-03
Journal Detail:
Title:  Theriogenology     Volume:  65     ISSN:  0093-691X     ISO Abbreviation:  Theriogenology     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-17     Completed Date:  2006-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421510     Medline TA:  Theriogenology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1265-78     Citation Subset:  IM    
Department of Animal Science, University of Basilicata, Campus Macchia Romana, 85100 Potenza, Italy.
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MeSH Terms
Brain / metabolism
D-Aspartic Acid / administration & dosage*,  analysis,  physiology*
Endocrine Glands / chemistry
Luteinizing Hormone / blood
N-Methylaspartate / analysis,  blood
Organ Specificity
Pineal Gland / chemistry
Pituitary Gland / chemistry
Progesterone / blood
Reproduction / drug effects,  physiology*
Sexual Behavior, Animal / drug effects,  physiology*
Sheep / physiology*
Reg. No./Substance:
1783-96-6/D-Aspartic Acid; 57-83-0/Progesterone; 6384-92-5/N-Methylaspartate; 9002-67-9/Luteinizing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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