Document Detail

D-amino acid oxidase: its potential in the production of 7-aminocephalosporanic acid.
MedLine Citation:
PMID:  12024974     Owner:  NLM     Status:  MEDLINE    
D-Amino acid oxidase (DAAO) used in the preparation of alpha-keto acids, in the determination of D-amino acids and in the resolution of racemic mixture of amino acids is produced by a wide range of microorganisms. In the recent past this enzyme is being recognized for its potential in the commercial production of 7-aminocephalosporanic acid (7-ACA), a starting material for various semisynthetic cephalosporins. Though this enzyme is widespread among microorganisms, very few microbial species have been explored for the production of 7-ACA; this is because cephalosporin C is quantitatively deaminated by limited microbial DAAOs. Comparison of physico-chemical properties of enzyme preparations indicate wide variations, however in general DAAOs are specific for D-configuration of amino acids. Both immobilized enzyme and cell preparations are developed for its various applications. The advantages of DAAO in the production of 7-ACA are discussed.
S K Mujawar
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Hindustan antibiotics bulletin     Volume:  41     ISSN:  0018-1935     ISO Abbreviation:  Hindustan Antibiot Bull     Publication Date:    1999 Feb-Nov
Date Detail:
Created Date:  2002-05-23     Completed Date:  2002-06-18     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  2985097R     Medline TA:  Hindustan Antibiot Bull     Country:  India    
Other Details:
Languages:  eng     Pagination:  1-14     Citation Subset:  IM    
Biochemistry Division, Research and Development, Hindustan Antibiotics Ltd., Pimpri, Pune 411 018, India.
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MeSH Terms
Bacteria / enzymology,  metabolism
Cephalosporins / biosynthesis*,  chemistry
D-Amino-Acid Oxidase / biosynthesis,  chemistry*
Reg. No./Substance:
0/Cephalosporins; 957-68-6/7-aminocephalosporanic acid; EC Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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