| D-amino acid oxidase: its potential in the production of 7-aminocephalosporanic acid. | |
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MedLine Citation:
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PMID: 12024974 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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D-Amino acid oxidase (DAAO) used in the preparation of alpha-keto acids, in the determination of D-amino acids and in the resolution of racemic mixture of amino acids is produced by a wide range of microorganisms. In the recent past this enzyme is being recognized for its potential in the commercial production of 7-aminocephalosporanic acid (7-ACA), a starting material for various semisynthetic cephalosporins. Though this enzyme is widespread among microorganisms, very few microbial species have been explored for the production of 7-ACA; this is because cephalosporin C is quantitatively deaminated by limited microbial DAAOs. Comparison of physico-chemical properties of enzyme preparations indicate wide variations, however in general DAAOs are specific for D-configuration of amino acids. Both immobilized enzyme and cell preparations are developed for its various applications. The advantages of DAAO in the production of 7-ACA are discussed. |
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Authors:
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S K Mujawar |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Hindustan antibiotics bulletin Volume: 41 ISSN: 0018-1935 ISO Abbreviation: Hindustan Antibiot Bull Publication Date: 1999 Feb-Nov |
Date Detail:
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Created Date: 2002-05-23 Completed Date: 2002-06-18 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 2985097R Medline TA: Hindustan Antibiot Bull Country: India |
Other Details:
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Languages: eng Pagination: 1-14 Citation Subset: IM |
Affiliation:
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Biochemistry Division, Research and Development, Hindustan Antibiotics Ltd., Pimpri, Pune 411 018, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacteria / enzymology, metabolism Cephalosporins / biosynthesis*, chemistry D-Amino-Acid Oxidase / biosynthesis, chemistry* Humans |
| Chemical | |
Reg. No./Substance:
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0/Cephalosporins; 957-68-6/7-aminocephalosporanic acid; EC 1.4.3.3/D-Amino-Acid Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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