Document Detail


D-psicose, a sweet monosaccharide, ameliorate hyperglycemia, and dyslipidemia in C57BL/6J db/db mice.
MedLine Citation:
PMID:  20492234     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
D-psicose has been implicated in glycemic control in recent animal and human studies. In this study, the effects of D-psicose on glycemic responses, insulin release, and lipid profiles were compared with those of D-glucose and D-fructose in a genetic diabetes model. C57BL/6J db/db mice were orally supplemented with 200 mg/kg BW of D-psicose, D-glucose, or D-fructose, respectively, while diabetes control or wild type mice were supplemented with water instead. D-psicose sustained weight gain by about 10% compared to other groups. The initial blood glucose level maintained from 276 to 305 mg/dL during 28 d in the D-psicose group, whereas a 2-fold increase was found in other groups (P < 0.05) among diabetic mice. D-psicose significantly improved glucose tolerance and the areas under the curve (AUC) for glucose among diabetes (P < 0.05), but had no effect on serum insulin concentration. The plasma lipid profile was not changed by supplemental monosacchrides, although the ratio of LDL-cholesterol/HDL-cholesterol was ameliorated by D-psicose. The administration of D-psicose reversed hepatic concentrations of triglyceride (TG) and total cholesterol (TC) by 37.88% and 62.89%, respectively, compared to the diabetes control (P < 0.05). The current findings suggest that D-psicose shows promise as an antidiabetic and may have antidyslipidemic effects in type 2 diabetes.
Authors:
S H Baek; S J Park; H G Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of food science     Volume:  75     ISSN:  1750-3841     ISO Abbreviation:  J. Food Sci.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-05-24     Completed Date:  2010-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0014052     Medline TA:  J Food Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H49-53     Citation Subset:  IM    
Affiliation:
Dept. of Food and Nutrition, Hanyang Univ., Seoul 133-791, Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Area Under Curve
Blood Glucose / drug effects
Body Weight / drug effects
Diabetes Mellitus, Experimental / metabolism*
Dietary Supplements*
Disease Models, Animal
Dyslipidemias / blood*,  prevention & control
Feces
Fructose / administration & dosage,  metabolism,  pharmacology*
Glucose / administration & dosage
Hyperglycemia / blood*,  prevention & control
Insulin / blood
Lipid Metabolism / drug effects
Liver / drug effects,  metabolism
Male
Mice
Mice, Inbred C57BL
Water / administration & dosage
Weight Gain / drug effects
Chemical
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 23140-52-5/psicose; 30237-26-4/Fructose; 50-99-7/Glucose; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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