| D-psicose, a sweet monosaccharide, ameliorate hyperglycemia, and dyslipidemia in C57BL/6J db/db mice. | |
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MedLine Citation:
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PMID: 20492234 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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D-psicose has been implicated in glycemic control in recent animal and human studies. In this study, the effects of D-psicose on glycemic responses, insulin release, and lipid profiles were compared with those of D-glucose and D-fructose in a genetic diabetes model. C57BL/6J db/db mice were orally supplemented with 200 mg/kg BW of D-psicose, D-glucose, or D-fructose, respectively, while diabetes control or wild type mice were supplemented with water instead. D-psicose sustained weight gain by about 10% compared to other groups. The initial blood glucose level maintained from 276 to 305 mg/dL during 28 d in the D-psicose group, whereas a 2-fold increase was found in other groups (P < 0.05) among diabetic mice. D-psicose significantly improved glucose tolerance and the areas under the curve (AUC) for glucose among diabetes (P < 0.05), but had no effect on serum insulin concentration. The plasma lipid profile was not changed by supplemental monosacchrides, although the ratio of LDL-cholesterol/HDL-cholesterol was ameliorated by D-psicose. The administration of D-psicose reversed hepatic concentrations of triglyceride (TG) and total cholesterol (TC) by 37.88% and 62.89%, respectively, compared to the diabetes control (P < 0.05). The current findings suggest that D-psicose shows promise as an antidiabetic and may have antidyslipidemic effects in type 2 diabetes. |
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Authors:
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S H Baek; S J Park; H G Lee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of food science Volume: 75 ISSN: 1750-3841 ISO Abbreviation: J. Food Sci. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-05-24 Completed Date: 2010-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0014052 Medline TA: J Food Sci Country: United States |
Other Details:
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Languages: eng Pagination: H49-53 Citation Subset: IM |
Affiliation:
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Dept. of Food and Nutrition, Hanyang Univ., Seoul 133-791, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Area Under Curve Blood Glucose / drug effects Body Weight / drug effects Diabetes Mellitus, Experimental / metabolism* Dietary Supplements* Disease Models, Animal Dyslipidemias / blood*, prevention & control Feces Fructose / administration & dosage, metabolism, pharmacology* Glucose / administration & dosage Hyperglycemia / blood*, prevention & control Insulin / blood Lipid Metabolism / drug effects Liver / drug effects, metabolism Male Mice Mice, Inbred C57BL Water / administration & dosage Weight Gain / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 11061-68-0/Insulin; 23140-52-5/psicose; 30237-26-4/Fructose; 50-99-7/Glucose; 7732-18-5/Water |
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