| D-Dimer levels at different stages of pregnancy in Australian women: A single centre study using two different immunoturbidimetric assays. | |
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MedLine Citation:
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PMID: 22704076 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: To date there is minimal data available on D-Dimer levels at different stages of pregnancy. PATIENTS AND METHODS: We prospectively measured D-Dimer levels in 632 consecutive pregnant women from March 2007 to January 2009. The median age of the participants was 31years (range; 18-42) with a median weight of 78 kilograms (range; 46-137). All subjects were investigated during each trimester with two different immunoturbidimetric assays; D-Dimer PLUS and INNOVANCE D-Dimer. D-Dimer levels were determined using a Sysmex® CA 1500 analyser. RESULTS: Our data demonstrate that D-Dimer levels in pregnancy show different patterns of rise within the first trimester, depending on the assay used; D-Dimer PLUS=0.88 (SD: mean ratio), INNOVANCE D-Dimer=0.72 (SD: mean ratio). Furthermore, the rise in mean results was greater for the INNOVANCE D-Dimer assay compared to the D-Dimer PLUS assay as shown by the ratio of third to first trimester results of 3.68 and 1.96 respectively. Both D-Dimer assays demonstrated moderate levels of intra-subject variability, with overall mean CVs of 16.5% (D-Dimer PLUS) and 16.9% (INNOVANCE D-Dimer). Furthermore, we studied the association between D-Dimer levels and occurrence of diseases of pregnancy. For both assays, there was no consistently interpretable evidence of an association between raised mean D-Dimer levels or rising D-Dimer levels and any of the diseases or conditions associated with pregnancy. CONCLUSION: Our data suggest that the INNOVANCE D-Dimer assay increases significantly with the advancement of pregnancy, and is more sensitive than D-Dimer PLUS assay in the pregnant population. |
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Authors:
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Alhossain A Khalafallah; Michael Morse; Abdul-Majeed Al-Barzan; Murray Adams; Amanda Dennis; Gerald Bates; Iain Robertson; David Seaton; Terry Brain |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-14 |
Journal Detail:
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Title: Thrombosis research Volume: - ISSN: 1879-2472 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0326377 Medline TA: Thromb Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Launceston General Hospital (LGH) Tasmania, Australia; School of Human Life Sciences, University of Tasmania, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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