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D: -Allose as ischemic retina injury inhibitor during rabbit vitrectomy.
MedLine Citation:
PMID:  21567229     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: To investigate the protective effects of D: -allose, a rare sugar, on pressure-induced ischemia during vitrectomy in the rabbit eye. METHODS: The rabbits underwent pars plana vitrectomy, and continuous intraocular irrigation at a perfusion pressure of 140 mmHg was performed for 45 min. Intraocular pressure was regulated by adjusting the height of a bottle of balanced saline solution containing D: -allose. Morphometric studies were performed to study the effects of D: -allose on the histological changes induced by ischemia in the rabbit retina. Electroretinograms (ERGs) were taken before and 1 and 7 days after vitrectomy. Nitroblue tetrazolium was used as an index of superoxide anion (O (2) (·-) ) generation. Data were analyzed by use of the unpaired Student's t test. RESULTS: Seven days after ischemia, significant reductions in both number of ganglion cells and the thickness of the inner plexiform layer were observed. D: -Allose significantly inhibited ischemic injury of the inner retina (P < 0.05). On postoperative day 7, amplitudes of ERG b-waves were significantly lower in the control group than in the D: -allose group (P < 0.05). D: -Allose suppressed the production of O(2) (-). CONCLUSIONS: Intraocular irrigation with D: -allose during vitrectomy may protect the retina against ischemia-induced damage.
Authors:
Masanori Mizote; Kazuyuki Hirooka; Kouki Fukuda; Takehiro Nakamura; Toshifumi Itano; Fumio Shiraga
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-13
Journal Detail:
Title:  Japanese journal of ophthalmology     Volume:  -     ISSN:  1613-2246     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0044652     Medline TA:  Jpn J Ophthalmol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Ophthalmology, Kagawa Prefectural Central Hospital, 5-4-16 Ban, Takamatu, Kagawa, 760-8557, Japan, m-mizote@chp-kagawa.jp.
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