Document Detail


Cytotoxin associated gene A-positive Helicobacter pylori strains in dyspeptic pregnant women.
MedLine Citation:
PMID:  15358462     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The aim of the present study was to compare the Helicobacter pylori (HP) seropositivity and cytotoxin associated gene A (cagA) status in pregnant women with dyspeptic complaints and pregnant women with no gastrointestinal symptoms. STUDY DESIGN: Seventy-one consecutive pregnant women with gastrointestinal complaints and 72 age-matched pregnant women without any gastrointestinal symptoms or a history of gastrointestinal disease were included in the study. Demographic characteristics and H. pylori and cytotoxin associated gene A status of the groups were analysed. RESULTS: The prevalence of H. pylori seropositivity was slightly but not significantly higher in patients with dyspeptic complaints compared to the controls (74.6% versus 63.8%, respectively, P > 0.05). The incidence of dyspeptic complaints were 53.5% in HP-seropositive and 40.9% in HP-seronegative women (P > 0.05). The prevalence of cytotoxin associated gene A positivity among H. pylori-seropositive women was significantly higher in dyspeptic pregnants compared to the controls (75.5% versus 45.7%, respectively, P = 0.002). Among HP-seropositive women, the incidence of dyspeptic complaints was significantly higher in cagA-positive patients compared to the cagA-negative ones (65.6% versus 34.2%, respectively, P = 0.002). When analysed according to the trimesters, the prevalence of cytotoxin associated gene A positivity among H. pylori-seropositive women was significantly higher in dyspeptic pregnants compared to the controls in the first trimester (68.0% versus 34.8%, respectively, P = 0.021). CONCLUSION: Cytotoxin associated gene A-positive, virulent H. pylori strains were found to be more frequently associated with dyspeptic complaints in pregnant women.
Authors:
Volkan Noyan; Teoman Z Apan; Aykan Yucel; Nevin Sagsoz
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  116     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-10     Completed Date:  2005-03-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  186-9     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Kirikkale University School of Medicine, Saglick Sokak, Kirikkale, Turkey. vnoyan@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Bacterial / blood
Antigens, Bacterial / blood*
Bacterial Proteins / blood*
Case-Control Studies
Dyspepsia / immunology*,  microbiology*
Female
Helicobacter Infections / complications,  immunology*,  microbiology
Helicobacter pylori / immunology*,  isolation & purification
Humans
Immunoglobulin G / blood
Incidence
Pregnancy
Pregnancy Complications, Infectious / immunology,  microbiology*
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Antigens, Bacterial; 0/Bacterial Proteins; 0/Immunoglobulin G; 0/cagA protein, Helicobacter pylori

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