| Cytotoxin associated gene A-positive Helicobacter pylori strains in dyspeptic pregnant women. | |
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MedLine Citation:
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PMID: 15358462 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of the present study was to compare the Helicobacter pylori (HP) seropositivity and cytotoxin associated gene A (cagA) status in pregnant women with dyspeptic complaints and pregnant women with no gastrointestinal symptoms. STUDY DESIGN: Seventy-one consecutive pregnant women with gastrointestinal complaints and 72 age-matched pregnant women without any gastrointestinal symptoms or a history of gastrointestinal disease were included in the study. Demographic characteristics and H. pylori and cytotoxin associated gene A status of the groups were analysed. RESULTS: The prevalence of H. pylori seropositivity was slightly but not significantly higher in patients with dyspeptic complaints compared to the controls (74.6% versus 63.8%, respectively, P > 0.05). The incidence of dyspeptic complaints were 53.5% in HP-seropositive and 40.9% in HP-seronegative women (P > 0.05). The prevalence of cytotoxin associated gene A positivity among H. pylori-seropositive women was significantly higher in dyspeptic pregnants compared to the controls (75.5% versus 45.7%, respectively, P = 0.002). Among HP-seropositive women, the incidence of dyspeptic complaints was significantly higher in cagA-positive patients compared to the cagA-negative ones (65.6% versus 34.2%, respectively, P = 0.002). When analysed according to the trimesters, the prevalence of cytotoxin associated gene A positivity among H. pylori-seropositive women was significantly higher in dyspeptic pregnants compared to the controls in the first trimester (68.0% versus 34.8%, respectively, P = 0.021). CONCLUSION: Cytotoxin associated gene A-positive, virulent H. pylori strains were found to be more frequently associated with dyspeptic complaints in pregnant women. |
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Authors:
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Volkan Noyan; Teoman Z Apan; Aykan Yucel; Nevin Sagsoz |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 116 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-09-10 Completed Date: 2005-03-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 186-9 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Kirikkale University School of Medicine, Saglick Sokak, Kirikkale, Turkey. vnoyan@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies, Bacterial / blood Antigens, Bacterial / blood* Bacterial Proteins / blood* Case-Control Studies Dyspepsia / immunology*, microbiology* Female Helicobacter Infections / complications, immunology*, microbiology Helicobacter pylori / immunology*, isolation & purification Humans Immunoglobulin G / blood Incidence Pregnancy Pregnancy Complications, Infectious / immunology, microbiology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial; 0/Antigens, Bacterial; 0/Bacterial Proteins; 0/Immunoglobulin G; 0/cagA protein, Helicobacter pylori |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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