| Cytotoxicity of several chemotherapeutic agents in a human pancreatic cancer cell line (Colo-357). | |
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MedLine Citation:
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PMID: 6697332 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Seven commonly available chemotherapeutic drugs were used to determine the concentration and time of exposure necessary to kill the newly available human pancreatic cancer cell line, Colo-357. The exposure periods were 2, 6, 12, and 24 hours. The most active drugs were methotrexate, mitomycin, and doxorubicin, each with an ID50 less than 0.1 microM for both a 12- and a 24-hour exposure. Cisplatin was intermediate, with an ID50 of approximately 0.7 microM at 12 and 24 hours. 5-FU, carmustine, and streptozocin were the least effective agents, with ID50 values greater than 50 microM after a 12-hour exposure and greater than 25 microM after a 24-hour exposure. |
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Authors:
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E Cadman; C Benz |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer treatment reports Volume: 68 ISSN: 0361-5960 ISO Abbreviation: Cancer Treat Rep Publication Date: 1984 Feb |
Date Detail:
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Created Date: 1984-04-02 Completed Date: 1984-04-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7607107 Medline TA: Cancer Treat Rep Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 429-30 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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therapeutic use* Cell Line Cell Survival / drug effects* Doxorubicin / therapeutic use Drug Evaluation Humans Methotrexate / therapeutic use Mitomycins / therapeutic use Pancreatic Neoplasms / drug therapy* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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CA-08341/CA/NCI NIH HHS; CA-27130/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Mitomycins; 23214-92-8/Doxorubicin; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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