| Cytotoxicity of lavender oil and its major components to human skin cells. | |
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MedLine Citation:
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PMID: 15144499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lavender (Lavandula angustifolia) oil, chiefly composed of linalyl acetate (51%) and linalool (35%), is considered to be one of the mildest of known plant essential oils and has a history in wound healing. Concerns are building about the potential for irritant or allergenic skin reactions with the use of lavender oil. This study has demonstrated that lavender oil is cytotoxic to human skin cells in vitro (endothelial cells and fibroblasts) at a concentration of 0.25% (v/v) in all cell types tested (HMEC-1, HNDF and 153BR). The major components of the oil, linalyl acetate and linalool, were also assayed under similar conditions for their cytotoxicity. The activity of linalool reflected that of the whole oil, indicating that linalool may be the active component of lavender oil. Linalyl acetate cytotoxicity was higher than that of the oil itself, suggesting suppression of its activity by an unknown factor in the oil. Membrane damage is proposed as the possible mechanism of action. |
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Authors:
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A Prashar; I C Locke; C S Evans |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cell proliferation Volume: 37 ISSN: 0960-7722 ISO Abbreviation: Cell Prolif. Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-05-17 Completed Date: 2004-06-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9105195 Medline TA: Cell Prolif Country: England |
Other Details:
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Languages: eng Pagination: 221-9 Citation Subset: IM |
Affiliation:
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School of Biosciences, University of Westminster, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Line Cell Membrane / drug effects Cell Survival / drug effects Dermatitis, Allergic Contact / etiology* Dose-Response Relationship, Drug Endothelial Cells / drug effects*, pathology Fibroblasts / drug effects*, pathology Humans Lavandula Monoterpenes / toxicity Oils, Volatile / toxicity* Plant Oils / toxicity* Skin / cytology* |
| Chemical | |
Reg. No./Substance:
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0/Monoterpenes; 0/Oils, Volatile; 0/Plant Oils; 115-95-7/linalyl acetate; 78-70-6/linalool; 8000-28-0/lavender oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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