| Cytotoxicity of Fe3O4/Au composite nanoparticles loaded with doxorubicin combined with magnetic field. | |
| | |
MedLine Citation:
|
PMID: 20662318 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
GoldMag (Fe3O4/Au) nanoparticles have the advantages of both magnetic response in an external magnetic field and the immobilization of molecules on their surface in a single step. The cytotoxicities of GoldMag nanoparticles and GoldMag nanoparticles loaded with doxorubicin (Dox-GoldMag) combined with an external magnetic field were tested in vitro on HepG2 malignant tumor cells. The results showed that cell viability remained above 92% when using GoldMag nanoparticles at a concentration as high as 2.0 mg/ml, suggesting the biocompatibility of the nanoparticles. The IC50 (0.731 microg/ml) of the Dox-GoldMag group was higher than that (0.522 microg/ml) of the Dox group (P < 0. 05). However, the Dox-GoldMag group combined with a magnetic field had an obviously increased inhibition rate for the HepG2 cell line and the IC50 was lower than that of the Dox group (0.421 microg/ml). These results indicated that GoldMag nanoparticles loaded with doxorubicin combined with a permanent magnetic field are more cytotoxic and could be a potential targeted drug delivery system. |
| | |
Authors:
|
Xu Chao; Feng Shi; Ying-Yong Zhao; Ke Li; Ming-Li Peng; Chao Chen; Ya-Li Cui |
Related Documents
:
|
17121758 - Craniospinal irradiation using a forward planned segmented field technique. 18779068 - Correction for resolution nonuniformities caused by anode angulation in computed tomogr... 10265668 - The special environmental needs of magnetic resonance. 15263518 - Magnetic measurement system for high-field magnets. 17061128 - Kinematic study following double-bundle, anterior cruciate ligament reconstruction. 18643188 - Negative index of refraction in metallic metamaterial comprising split-ring resonators. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Die Pharmazie Volume: 65 ISSN: 0031-7144 ISO Abbreviation: Pharmazie Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-07-28 Completed Date: 2010-09-15 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9800766 Medline TA: Pharmazie Country: Germany |
Other Details:
|
Languages: eng Pagination: 500-4 Citation Subset: IM |
Affiliation:
|
The College of Life Sciences, Northwest University, No.229 Taibai North Road, Xi'an 710069, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antibiotics, Antineoplastic
/
administration & dosage*,
toxicity* Cell Line, Tumor Doxorubicin / administration & dosage*, toxicity* Electromagnetic Fields* Ferrous Compounds / toxicity* Gold / toxicity* Humans Indicators and Reagents Kinetics Microscopy, Electron Nanoparticles Solubility |
| Chemical | |
Reg. No./Substance:
|
0/Antibiotics, Antineoplastic; 0/Ferrous Compounds; 0/Indicators and Reagents; 1345-25-1/ferrous oxide; 23214-92-8/Doxorubicin; 7440-57-5/Gold |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Preparation and characterization of paclitaxel delivery system based on semi-solid lipid nanoparticl...
Next Document: Mucoadhesion on urinary bladder mucosa: the influence of sodium, calcium, and magnesium ions.